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Citation: IMERHASAN Mukhtar, OSMAN Kurban, MUHAMMAD Turghun, HELIL Setiwaldi, HAYDAR Gulbostan. Synthesis and Bioactivity of Novel Pyrrolino[3',4'-d] isoxazole Derivatives with Carboxyl or Ester Groups[J]. Chinese Journal of Applied Chemistry, ;2008, 25(8): 931-936. shu

Synthesis and Bioactivity of Novel Pyrrolino[3',4'-d] isoxazole Derivatives with Carboxyl or Ester Groups

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a College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046;
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b Department of Life and Environmental Science, Kashgar Teachers College, Kashgar;
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c College of Life Sciences, Xinjiang Normal University, Urumqi

Corresponding author: IMERHASAN Mukhtar,
Received Date: 6 August 2007
Available Online: 14 March 2008
Fund Project: 新疆维吾尔自治区自然科学基金资助项目(200421126) (200421126)

Fourteen novel 5-aryl-3a,6a-dihydro-4,6-dioxo-pyrrolino[3',4'-d] isoxazole-3-carboxy-lic acid derivatives(3a~3g) and ethyl 5-aryl-3a,6a-dihydro-4,6-dioxo-pyrrolino[3',4'-d] isoxazole-3-carboxylate derivatives(4a~4g) were synthesized by 1,3-dipolar cycloaddition reaction of N-arylmaleimides with isonitrosochloroacetic acid or ethyl chloro oximino acetate. The structures of compounds 3 and 4 were confirmed by ¹H NMR, IR and elemental analysis. Preliminary bioassay was tested for the target compounds. The bioassay indicates that compounds 3a, 3b, 3c showed 100% antitumor activity at the test concentration(10 μmol/L). Compounds 3d, 3e and compounds 4a, 4d, 4e showed different inhibiting effects(61.47%, 66.23%, 18.92%, 22.49%, 56.43%) on cell division cycle 25A at the test concentration(2×10^-5 g/mL) and the structure-activity relationship of the compounds was investigated.
- carboxyl,
- estergroup,
- dioxo-pyrrolino[3',4'-d] isoxazole,
- synthesis,
- bioactivity
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