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Citation: LIU Ying, WEI Rong-Qing, LIU Xiao-Ning, WAN Yuan-Song. Analysis of Lactic Acid Content in L-Lactide[J]. Chinese Journal of Applied Chemistry, ;2008, 25(9): 1104-1106. shu

Analysis of Lactic Acid Content in L-Lactide

1.
College of Life Science and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009

Corresponding author: LIU Xiao-Ning,
Received Date: 15 August 2007
Available Online: 8 November 2007
Fund Project: 科技部创新基金(05C26213200578) (05C26213200578)江苏省工业科技攻关项目基金(BE2005048)资助项目 (BE2005048)

Determination of lactic acid residue in L-lactide is necessary in controlling its purity and the quality in applications.In the presence of lactide,the method referred in GB2023-2003 to determine lactic acid content with back-titration by strong acid is improper;meanwhile the lactic acid content in lactide determined by sodium alkoxide titration reported previously appeared to be lower than the exact value.The two titration methods were correlated by a coefficent of P=1.228 and the method of quantitative determination of lactic acid in lactide by "titration-convert" was proposed.The result indicated the lactic acid content in lactide crystals and mother liquid decreased with recrystallization cycle.After 3 recrystallization cycles,the content of lactic acid was constant.The lactide met the requirement of polymerization with a lactic acid content of <1.0%,and polylactic acid with M_η up to 3×10⁵ was obtained when the lactic acid content was <0.4%.
- L-lactide,
- lactic acid,
- the content of lactic acid,
- titration-convert,
- sodium alkoxide
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