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Citation: LI Dong-Hong, DIAO Jun-Lin, LIU Jian-Cang. Preparation of Magnetic Nanoparticles Loading Photosensitizer and Their Photodynamic Activity[J]. Chinese Journal of Applied Chemistry, ;2008, 25(9): 1065-1068. shu

Preparation of Magnetic Nanoparticles Loading Photosensitizer and Their Photodynamic Activity

1.
State Key Laboratory of Trauma, Burn and Combined Injury, the 2nd Department of Research Institute of Surgery, the Third Military Medical University(Daping Hospital), Chongqing 400042

Corresponding author: LI Dong-Hong,
Received Date: 28 September 2007
Available Online: 9 December 2007
Fund Project: 重庆市自然科学基金资助课题(2005BB5026) (2005BB5026)

Tetra-(p-hydroxylphenyl)porphyrin photosensitizer loaded with magnetic nanoparticles were prepared by means of emulsification and chemical co-precipitation.The morphology and size of the nanoparticles were analyzed by transmission electronic microscopy and X-ray diffraction,and their chemical structures were also analyzed by infrared spectroscopy.The magnetic response property was observed on a vibrating samples magnetometer.The content of photosensitizer was measured by UV-Vis spectrum.Their photodynamic activity against human Lovo colonic-carcinoma cell line in vitro was evaluated by MTT assay.The results reveal that the magnetic nanoparticles are regular sphere with a size of smaller than 50 nm,and the Fe₃O₄ particles were coated by the Dextran-40,the mass magnetic susceptibility was 68.27 emu/g,the content of porphyrin photosensitizer was 8.5%.The growth inhibitory rate of Volo cells was 81.85% after they were treated with magnetic nanoparticles,in which 1×10^-6 mol/L of tetra-(p-hydroxylphenyl)porphyrin was loaded,followed by irradiation of visible light for 30 min.
- tetra-(p-hydroxylphenyl)porphyrin,
- magnetic nanoparticle loading photosensitizer,
- preparation,
- performance,
- photodynamic activity in vitro
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