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Citation: WANG Ru-Lin, SUN Ti-Jian, PEI Xiao-Li, DIAO Hai-Peng, CHEN Ming-Lan. Inclusion Interaction of Meloxicam with β-Cyclodextrin Derivatives[J]. Chinese Journal of Applied Chemistry, ;2008, 25(10): 1221-1224. shu

Inclusion Interaction of Meloxicam with β-Cyclodextrin Derivatives

1.
a Department of Chemistry, Shanxi Medical University, Taiyuan 030001;
2.
b Experimental Centre, Shanxi Traditional Chinese Medicine College, Taiyuan

Corresponding author: SUN Ti-Jian,
Received Date: 11 October 2007
Available Online: 15 January 2008
Fund Project: 山西省科技厅自然科学基金(20051029)资助项目 (20051029)

In phosphate buffer midia the inclusion behavior beween meloxicam and β-cyclodextrin(β-CD),hydroxyproyl-β-cyclodextrin(HP-β-CD) and sulfobutyl ether-β-cyclodextrin(SBE-β-CD) was studied by fluorescence spectroscopy.It showed that 1:1 inclusion complexes were formed beween meloxicam and the three kinds of CDs,because the emission maximum shifted by 7,9,and 14 nm,respectively and the reciprocal of change in fluorescence intensity(ΔF) was directly proportional to the reciprocal of the CD concentration(CCD).The binding ability was SBE-β-CD > HP-β-CD > β-CD in acidic and neutral media based on the formation constants.There were not only hydrophobic but also electrostatic forces involved.
- meloxicam,
- β-cyclodextrin derivatives,
- inclusion interaction,
- fluorescence spectrum
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