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Citation: LI Guo-Ming, LIU Cong, LIN Yue, GAO Hui-Chun, LUO Xiao-Wei, WANG Chao-Yang. Preparation of Amitriptyline Hydrochloride/Alginate/Chitosan Microspheres and Their Drug-Releasing Performance[J]. Chinese Journal of Applied Chemistry, ;2008, 25(11): 1351-1355. shu

Preparation of Amitriptyline Hydrochloride/Alginate/Chitosan Microspheres and Their Drug-Releasing Performance

1.
College of Chemical and Environmental Science, South China Normal University, Guangzhou 510631

Corresponding author: LI Guo-Ming,
Received Date: 8 October 2007
Available Online: 31 January 2008
Fund Project: 广东省自然科学基金资助项目(5300082) (5300082)

With a tricyclic antidepressant amitriptyline hydrochloride(AH) as the model drug,Alginate as the inside layer,and chitosan as the outside layer,amitriptyline hydrochloride-Alginate-chitosan microspheres were prepared by emulsion cross-linking technique with ethylene glycol diglycidyl ether(EGDE) as the cross-linking agent.The physicochemical properties and the drug-release performance of the microspheres were investigated.The microspheres had a spherical shape and were white in color,and the averaged diameter was about 18.70 μm.The drug content was 9.5%(mass fraction) and the drug loading efficiency could reach 53.25%.XRD analysis indicated that the AH in the microspheres were amorphous.The microspheres had a satisfactory performance of slowly releasing the AH.With the increase of the concentration of Alginate,the releasing rate of amitriptyline hydrochloride decreased;with the increase of pH,the releasing rate of amitriptyline hydrochloride increased;with the increase of the ratio of amitriptyline hydrochloride to Alginate by weight,the releasing rate of AH increased.The release rate of AH in acidic buffer was faster than that of AH in alkaline buffer.
- amitriptyline hydrochloride,
- alginate,
- chitosan,
- microspheres,
- cross-linking,
- ethylene glycol diglycidyl ether
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