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Citation: WANG Xin-Long, ZHANG Yue-Jun. Interactions of Hydrophobically Associating Poly(DMDAAC-NVP-IOA) with Naproxen and Its Drug Release Characteristics[J]. Chinese Journal of Applied Chemistry, ;2008, 25(12): 1393-1398. shu

Interactions of Hydrophobically Associating Poly(DMDAAC-NVP-IOA) with Naproxen and Its Drug Release Characteristics

WANG Xin-Long ^, ,
ZHANG Yue-Jun

1.
College of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094

Corresponding author: WANG Xin-Long,
Received Date: 27 December 2007
Available Online: 5 May 2008
Fund Project: 国家科技攻关项目(2003BA327C) (2003BA327C)

Poly(DMDAAC-NVP-IOA) was prepared from dimethyldiallylammonium chloride(DMDAAC),N-vinyl pyrrolidone(NVP) and isooctyl acrylate(IOA) via radical micellar polymerization in water.The polyelectrolyte and hydrophobic association properties of the polymer were studied.The interactions of P(DMDAAC-NVP-IOA) with naproxen were investigated by IR,XRD and DSC.As the amount of P(DMDAAC-NVP-IOA) increased,the peak at 1 684 cm^-1 assigned to the carbonyl of naproxen became broader and the peak intensity decreased.The diffraction peaks between 12° and 29° in the XRD pattern also became wider and even disappeared.There was only one transition observed by DSC with the increase of the amount of the polymer.All these results suggest the presence of interactions at molecular level between P(DMDAAC-NVP-IOA) and naproxen.Sustained-release tablets by naproxen were prepared from the copolymer and naproxen,and the drug release results suggest that the sustained-release tablets in the presence of P(DMDAAC-NVP-IOA) exhibit excellent properties in phosphate buffer,and the kinetics can be fit to a diffusion-erosion model.
- hydrophobically associating,
- water-soluble polymer,
- naproxen,
- sustained-release
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Interactions of Hydrophobically Associating Poly(DMDAAC-NVP-IOA) with Naproxen and Its Drug Release Characteristics

南开大学师唯/华北电力大学（保定）刘景维：二维配位聚合物中有序的亲锂冠醚位点用于无枝晶锂沉积

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通讯作者: 陈斌, bchen63@163.com