Citation: Chao Wu, Zhi-Wu Liang, Ying-Ying Xu, Wei-Min He, Jian-Nan Xiang. Gold-catalyzed oxazoles synthesis and their relevant antiproliferative activities[J]. Chinese Chemical Letters, ;2013, 24(12): 1064-1066. shu

Gold-catalyzed oxazoles synthesis and their relevant antiproliferative activities

1.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

Corresponding author: Wei-Min He, Jian-Nan Xiang,
Received Date: 3 May 2013
Available Online: 5 June 2013
Fund Project: This work was supported by NSFC (No. 21276068) (No. 21276068)Hunan Natural Science Foundation (No. 11JJ5008). (No. 2010SK2001)

Nine 5-aryl-2-methyloxazole derivatives were synthesized via gold-catalyzed alkyne oxidation. All of the compounds have been screened for their antiproliferative activities against MCF-7 cell (human breast carcinoma), A549 cell (human lung carcinoma) and Hela cell (human cervical carcinoma) lines in vitro. The results revealed that compounds 1b,1c and 1d exhibited strong inhibitory activities against the MCF-7 cell lines (with IC₅₀ values of 4.6, 9.7 and 2.2 μmol/L, respectively).
- Oxazole,
- Synthesis,
- Gold-catalyzed,
- Biological activity
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