Citation: Min Ou, Chun Zhu, Qi-Long Zhang, Bi-Xue Zhu. Synthesis and characterization of macrocyclic compounds with a hydroxyl functional group[J]. Chinese Chemical Letters, ;2013, 24(10): 869-872. shu

Synthesis and characterization of macrocyclic compounds with a hydroxyl functional group

Min Ou ^a ,
Chun Zhu ^a ,
Qi-Long Zhang ^b ,
Bi-Xue Zhu ^a,,

1.
a Key Laboratory of Macrocyclic and Supramolecular Chemistry, Guizhou University, Guiyang 550025, China;
2.
b Department of Chemistry, Guiyang Medical College, Guiyang 550004, China

Corresponding author: Bi-Xue Zhu,
Received Date: 19 April 2013
Available Online: 21 May 2013
Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21061003) (No. 21061003) the International Collaborative Project of Guizhou Province (No. [2009]700104) (No. [2009]700104)the Natural Science Foundation of the Guizhou Province (No. (2012)2151). (No. (2012)

A novel [1+1] Schiff-base macrocyclic compound 3 has been synthesized from precursor 1, 1,3-bis(2'-formylphenoxy)-2-propanol, and precursor 2, resorcinol-bis(4-aminophenyl)ether, via condensation and cyclizaction using Ba²⁺ as template. The macrocycle 3 was further reduced giving saturated macrocycle 4. The structures of 3 and 4 were characterized by elemental analysis, ¹H NMR, IR, and MS spectra, and their structures were determined via single crystal X-ray diffraction studies. X-ray diffraction analysis revealed that the macrocyclic compound 3 has a folded conformation, and the corresponding reduced product 4 adopts a twisted and folded conformation due to its flexible nature.
- Schiff base,
- Macrocyclic compound,
- Synthesis,
- Structure
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