Citation: Subba Rao Devineni, Srinivasulu Doddaga, Rajasekhar Donka, Naga Raju Chamarthi. CeCl₃·7H₂O-SiO₂： Catalyst promoted microwave assisted neat synthesis, antifungal and antioxidant activities of α-diaminophosphonates[J]. Chinese Chemical Letters, ;2013, 24(8): 759-763. shu

CeCl₃·7H₂O-SiO₂： Catalyst promoted microwave assisted neat synthesis, antifungal and antioxidant activities of α-diaminophosphonates

1.
Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India

Corresponding author: Srinivasulu Doddaga,
Received Date: 5 March 2013
Available Online: 16 April 2013

CeCl₃·7H₂O supported on silica (CeCl₃·7H₂O-SiO₂) is used as a heterogeneous, efficient and recyclable catalyst for a three component one-pot reaction of an amine, aldehydes and diethyl phosphite to synthesize a-diaminophosphonate derivatives under microwave irradiation exploiting neat reaction conditions. Ten α-diaminophosphonates (6a-j) of 4,4'-sulfonyldianiline (Dapsone) (3.) were synthesized and structural elucidation was confirmed by spectral data. Antifungal and antioxidant activities were evaluated include minimum inhibitory concentrations and IC₅₀ values, respectively of the titled compounds. Compounds 6h, 6i exhibited promising antioxidant activity at lower IC₅₀ values 53.7 μg/mL, 53.2 μg/mL, respectively as compared with standard IC₅₀ value 51.6 μg/mL.
- α-Diaminophosphonates,
- Green synthesis,
- Kabachnik-Fields reaction,
- Antifungal activity,
- Antioxidant activity
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CeCl3·7H2O-SiO2： Catalyst promoted microwave assisted neat synthesis, antifungal and antioxidant activities of α-diaminophosphonates

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通讯作者: 陈斌, bchen63@163.com

CeCl₃·7H₂O-SiO₂： Catalyst promoted microwave assisted neat synthesis, antifungal and antioxidant activities of α-diaminophosphonates