Citation: Guo-Hua Zhang, Rui-Xia Hou, Dan-Xia Zhan, Yang Cong, Ya-Jun Cheng, Jun Fu. Fabrication of hollow porous PLGA microspheres for controlled protein release and promotion of cell compatibility[J]. Chinese Chemical Letters, ;2013, 24(8): 710-714. shu

Fabrication of hollow porous PLGA microspheres for controlled protein release and promotion of cell compatibility

1.
a Polymers and Composites Division, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China;
2.
b School of Chemical Engineering, Ningbo University of Technology, Ningbo 315016, China

Corresponding author: Jun Fu,
Received Date: 28 March 2013
Available Online: 3 May 2013

This letter reports on the fabrication of hollow, porous and non-porous poly(D,L-lactide-co-glycolide) (PLGA) microspheres (MSs) for the controlled release of protein and promotion of cell compatibility of tough hydrogels. PLGA MSs with different structures were prepared with modified double emulsion methods, using bovine serum albumin (BSA) as a porogen during emulsification. The release of the residual BSA from PLGA MSs was investigated as a function of the MS structure. The hollow PLGA MSs show a faster protein release than the porous MSs, while the non-porous MSs have the slowest protein release. Compositing the PLGA MSs with poly(vinyl alcohol) (PVA) hydrogels promoted chondrocyte adhesion and proliferation on the hydrogels.
- PLGA microspheres,
- Controlled release,
- Hydrogel,
- Cell compatibility
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沈阳化工大学材料科学与工程学院沈阳 110142