Citation: Zhang Qian, Yu Yanting, Li Jiale, Li Dong. The C5 C-H Bond Functionalization of Quinolines under Transition-Metal Free Conditions[J]. Chemistry, ;2020, 83(7): 615-620. shu

The C5 C-H Bond Functionalization of Quinolines under Transition-Metal Free Conditions

School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan, 430068

Corresponding author: Li Dong, dongli@mail.hbut.edu.cn
Received Date: 5 February 2020
Accepted Date: 9 March 2020

Quinoline is an important class of heterocyclic compounds, and research on the synthesis of quinoline compounds has attracted much attention. It is simple and efficient to prepare substituted quinolines though direct C-H bond functionalization of quinolines. However, the C5-selective C-H bond functionalization of quinolines is still a challenge. Most current methods are achieved by transition metal catalysis. The reactions under transition metal-free conditions are desired. In this paper, the recent advance of C5 C-H bond functionalization of quinolines under transition-metal free conditions is reviewed according to the types of bond (C-X, C-N, C-S, C-O and C-C) formation. And the research status and current problems in this field are also summarized.
- Quinoline,
- Transition-metal free,
- C-H bond functionalization,
- C5 of quinoline
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