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Citation: Mao Yuanhu, Wang Lili, Tang Lei, Liu Lang, Zhang Jiquan. New Procedure for Synthesis of Resveratrol[J]. Chemistry, ;2020, 83(2): 183-185. shu

New Procedure for Synthesis of Resveratrol

Mao Yuanhu ^1,2 ,
Wang Lili ³ ,
Tang Lei ² ,
Liu Lang ¹ ,
Zhang Jiquan ^1,2,,

1.
School of Pharmacy, Guizhou Medical University
2.
Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D
3.
School of Medicine and Health Management, Guizhou Medical University, Guiyang, 550004

Corresponding author: Zhang Jiquan, zjqgmc@163.com
Received Date: 24 April 2019
Accepted Date: 15 November 2019

Figures(1)

This study disclosed a new method for the synthesis of resveratrol. The key intermediate N'-(3, 5-dimethoxyphenyl)acetohydrazide (4) was obtained by using 3, 5-dimethoxyaniline as the starting material via diazotization, reduction and acetylation, which was condensed with 4-methoxystyrene to give the intermediate 5 via Mizoroki-Heck coupling reaction. The titled compound resveratrol (1) was prepared by final demethylation of 5 with a total yield of 31.9%. The structure of the intermediates and target product were confirmed by mass spectrum (MS) and ¹H NMR. This procedure is characterized by handy operations and mild conditions, and can be used for the scale-up preparation of resveratrol.
- Resveratrol,
- Diazotization,
- Mizoroki-Heck coupling reaction,
- Synthesis
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