Citation: Chen Zhijuan, Gu Bei, Zhang Yanan, Chen Qiang. Effect of Zwitterionic Compounds on Pepsin Activity[J]. Chemistry, ;2018, 81(5): 472-475. shu

Effect of Zwitterionic Compounds on Pepsin Activity

Chen Zhijuan ¹ ,
Gu Bei ¹ ,
Zhang Yanan ¹ ,
Chen Qiang ^1,2,3,,

1.
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023
2.
High-Tech Research Institute of Nanjing University, Changzhou 213164
3.
Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing 210046

Corresponding author: Chen Qiang, chem100@nju.edu.cn
Received Date: 18 December 2017
Accepted Date: 26 February 2018

Figures(5)

Enzyme is an important active substance in nature, its structures and properties are easily affected by the external environment. Now it is one of the hot topics in the research to increase and maintain enzyme activity. In this paper, pepsin was used as a model to study the effect of zwitterionic compounds such as methacryloyloxyethyl phosphorylcholine (MPC), sulfobetaine methacrylate (SBMA), carboxybetaine methacrylate (CBMA) on pepsin activity. The results showed that the pepsin activity in the presence of CBMA was 453% of the control after 2h at 60℃, and still 330% of the control pepsin after 6 h at 60℃. CBMA could significantly increase pepsin activity.
- Zwitterionic compounds,
- CBMA,
- Pepsin,
- Activity
1. [1]
  M Claude, R Lupi, G Bouchaud et al. Food Chem., 2016, 203:136~144.
2. [2]
  M Ciolkowski, M Rozanek, M Bryszewska et al. BBA-Proteins Proteom., 2013, 1834:1982~1987.
3. [3]
  L L Shen, H Xu, F W Huang et al. Spectrochim. Acta Part A, 2015, 135:256~263.
4. [4]
  Y Q Wang, H M Zhang. J. Agr. Food Chem., 2013, 61(46):11191~11200.
5. [5]
  N Johnston, P W Dettmar, B Bishwokarma et al. Laryngoscope, 2007, 117(6):1036~1039.
6. [6]
7. [7]
8. [8]
  H K Al-Hakeim, K M Jasem et al. Revista Colombiana De Quimica, 2016, 45(3):5~11.
9. [9]
  J Suliburska, P Bogdanski, S R Moustafa et al. Acta Pol. Pharm., 2012, 69(6):1049~1053.
10. [10]
  S Y Jiang, Z Q Cao. Adv. Mater., 2010, 22(9):920~932.
11. [11]
  J Ladd, Z Zhang, S Chen et al. Biomacromolecules, 2008, 9(5):1357~1361.
12. [12]
13. [13]
  Y Y Jiang, H X Lu, F Chen et al. Biomacromolecules, 2016, 17(3):807~808.
14. [14]
15. [15]
  S Y Liu, S Y Jiang. Nano Today, 2016, 11:285~291.
16. [16]
  M C Sin, P T Lou, C H Cho et al. Colloids Surf. B, 2015, 127:54~64.
17. [17]
18. [18]
1. [1]
  Lihua HUANG , Jian HUA . Denitration performance of HoCeMn/TiO₂ catalysts prepared by co-precipitation and impregnation methods. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 629-645. doi: 10.11862/CJIC.20230315
2. [2]
  Quanliang Chen , Zhaohui Zhou . Research on the Active Site of Nitrogenase over Fifty Years. University Chemistry, 2024, 39(7): 287-293. doi: 10.3866/PKU.DXHX202310133
3. [3]
  Haitang WANG , Yanni LING , Xiaqing MA , Yuxin CHEN , Rui ZHANG , Keyi WANG , Ying ZHANG , Wenmin WANG . Construction, crystal structures, and biological activities of two Ln^Ⅲ₃ complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1474-1482. doi: 10.11862/CJIC.20240188
4. [4]
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5. [5]
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6. [6]
  Xinting XIONG , Zhiqiang XIONG , Panlei XIAO , Xuliang NIE , Xiuying SONG , Xiuguang YI . Synthesis, crystal structures, Hirshfeld surface analysis, and antifungal activity of two complexes Na(Ⅰ)/Cd(Ⅱ) assembled by 5-bromo-2-hydroxybenzoic acid ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1661-1670. doi: 10.11862/CJIC.20240145
7. [7]
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8. [8]
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9. [9]
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10. [10]
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11. [11]
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12. [12]
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14. [14]
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15. [15]
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16. [16]
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17. [17]
  Xin MA , Ya SUN , Na SUN , Qian KANG , Jiajia ZHANG , Ruitao ZHU , Xiaoli GAO . A Tb₂ complex based on polydentate Schiff base: Crystal structure, fluorescence properties, and biological activity. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1347-1356. doi: 10.11862/CJIC.20230357
18. [18]
  Hong RAO , Yang HU , Yicong MA , Chunxin LÜ , Wei ZHONG , Lihua DU . Synthesis and in vitro anticancer activity of phenanthroline-functionalized nitrogen heterocyclic carbene homo- and heterobimetallic silver/gold complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2429-2437. doi: 10.11862/CJIC.20240275
19. [19]
  Xiaohui Li , Ze Zhang , Jingyi Cui , Juanjuan Yin . Advanced Exploration and Practice of Teaching in the Experimental Course of Chemical Engineering Thermodynamics under the “High Order, Innovative, and Challenging” Framework. University Chemistry, 2024, 39(7): 368-376. doi: 10.3866/PKU.DXHX202311027
20. [20]
  Rong Tian , Yadi Yang , Naihao Lu . Comprehensive Experimental Design of Undergraduate Students Based on Interdisciplinarity: Study on the Effect of Quercetin on Chlorination Activity of Myeloperoxidase. University Chemistry, 2024, 39(8): 247-254. doi: 10.3866/PKU.DXHX202312064

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