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Citation: ZHENG Aping, CHEN Bingnian, CHEN Fahe, WANG Li. Inhibition Effect of Vanadate-replaced Polyoxometalates on Mushroom Tyrosinase[J]. Chinese Journal of Applied Chemistry, ;2013, 30(2): 165-170. doi: DOI:10.3724/SP.J.1095.2013.20160 shu

Inhibition Effect of Vanadate-replaced Polyoxometalates on Mushroom Tyrosinase

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a School of Bioengineering, Jimei University, Xiamen 361021, China;
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b Yanwu Affiliated Hospital of Zhongshan Hospital Xiamen University(Xiamen University Hospital), Xiamen 361005, China

Corresponding author: WANG Li,
Received Date: 18 April 2012
Available Online: 1 June 2012
Fund Project: 国家自然科学基金(20871054) (20871054)福建省自然科学基金(JK2011027,2012J01045)资助项目 (JK2011027,2012J01045)

Three kinds vanadate-replaced polyoxometalates,α-1,2,3-K₆H[SiW₉V₃O₄₀],α-1,2-K₆[SiW₁₀V₂O₄₀] and α-K₅[SiW₁₁VO₄₀](abbreviated as α-SiW₉V₃,α-SiW₁₀V₂,α-SiW₁₁V) were synthesized and evaluated as tyrosinase inhibitors using the enzymological kinetic method.The results demonstrate that α-SiW₉V₃ can inhibit tyrosinase strongly,as demonstrated by the inhibition of the steady-state activity of the enzyme and the lengthening of the lag time.The IC₅₀ of α-SiW₉V₃ was estimated to be 0.6841 mmol/L for the inhibition of mushroom tyrosinase.It resulted in the lag time of the monophenolase extension from 235 s to 650 s with 0.7 mmol/L of α-SiW₉V₃.The inhibition of α-SiW₉V₃ on monophenolase of mushroom tyrosinase proceeds as reversible process,and the inhibition of α-SiW₉V₃ is a competitive-uncompetitive mixed-Ⅱ type due to the oxidation of L-tyrosine.The inhibition constants(K_I and K_IS) are determined to be 4.22 mmol/L and 2.39 mmol/L,respectively.As for the α-SiW₁₀V₂,however,it is unsoluble in DMSO buffer,and its effect on the mushroom tyrosinase cannot be studied.While the inhibition ability of α-SiW₁₁V on tyrosinase activity is rather weak.
- polyoxometalates,
- mushroom tyrosinase,
- monophenolase activity,
- inhibition effect
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