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Citation: WU Yuqin, CHEN Jinlong. Sensitive Detection of L-Cysteine by Using Blue Luminescent Gold Quantum Dots[J]. Chinese Journal of Applied Chemistry, ;2013, 30(2): 225-231. doi: DOI:10.3724/SP.J.1095.2013.20127 shu

Sensitive Detection of L-Cysteine by Using Blue Luminescent Gold Quantum Dots

WU Yuqin ^a ,
CHEN Jinlong ^b,c,,

1.
a Zhejiang Giian Test Institute Co., Ltd, Hangzhou 310021, China;
2.
b College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;
3.
c College of Chemical and Chemical Eginerring, Anqing Normal University, Anqing 246001, China

Corresponding author: CHEN Jinlong,
Received Date: 31 March 2012
Available Online: 21 May 2012
Fund Project: 安徽省教育厅基金资助项目(2008jp1101) (2008jp1101)中国药科大学博士科研启动项目(211166) (211166)

Blue luminescent gold(Au) quantum dots(QDs) were facilely prepared through a one-pot synthesis at room temperature.The as prepared Au QDs were well water-soluble and biocompatable.The mean size of Au QDs is about 3.0 nm.Gold QDs colloids showed a considerable blue fluorescence emission at 430 nm under excitation of 305 nm.Experimental results demonstrated that the addition of L-cysteine could significantly enhance the characteristic emission of Au QDs at 430 nm.Therein,a simple,rapid,sensitive detection of L-cysteine in aqueous solution was established.Under optimized conditions,the characteristic fluorescence intensity of Au QDs at 430 nm is linearly proportional to the concentration of L-cysteine in the range of 0.0 to 4.0×10^-6 μmol/L and a detection limit as low as 5 nmol/L was obtained.The relative linear relationship coefficient is 0.9976.The relative standard deviation for 11 replicate detections of 2.0 μmol/L L-cysteine was 2.8%.In addition,this method also demonstrated a high selectivity to amino acids due to the strong affinity of L-cysteine to gold atoms.
- Au quantum dots,
- fluorescence,
- L-cysteine,
- biosensor
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