Citation: Leung Man Pan, Yeung Chung Chiu, Choy Pui Ying, So Chau Ming, Kwong Fuk Yee. Facile One-Pot Assembly of New 5-Substituted P, O-Type Indolylphosphine Ligands for Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of Aryl Chlorides[J]. Chinese Journal of Organic Chemistry, ;2020, 40(10): 3338-3346. doi: 10.6023/cjoc202005069 shu

Facile One-Pot Assembly of New 5-Substituted P, O-Type Indolylphosphine Ligands for Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of Aryl Chlorides

a.
Department of Chemistry, The Chinese University of Hong Kong, Hong Kong
b.
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong

Corresponding author: Kwong Fuk Yee, fykwong@cuhk.edu.hk
Received Date: 26 May 2020
Revised Date: 3 July 2020
Available Online: 15 July 2020
Fund Project: the General Research Fund (GRF) from Research Grants Council of Hong Kong (RGC) 14304519Project supported by the Guangdong Basic and Applied Basic Research Foundation (No. 2019A1515011357), and the General Research Fund (GRF) from Research Grants Council of Hong Kong (RGC) (No. 14304519)the Guangdong Basic and Applied Basic Research Foundation 2019A1515011357

Figures(3)

A series of P, O-type indolylphosphine ligands with different substituted variants have been synthesized by a simple one-pot protocol from readily available and inexpensive materials. These ligands show "substituent effect" with respected to the efficacy in promoting palladium-catalyzed Suzuki-Miyaura cross-coupling of aryl chlorides. This new Pd/L1 catalyst system particularly allows the catalyst loading reaching the level of 0.01 mol% Pd.
- palladium,
- ligand design,
- cross-coupling,
- phosphine,
- P, O-ligand
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