Citation: Li Jian, He Long, Zhou Zhiqiang, Zhen Yanxia, Xie Weiqing. Advances in the Synthesis of Anislactone-Type Sesquiterpenes[J]. Chinese Journal of Organic Chemistry, ;2020, 40(10): 3166-3176. doi: 10.6023/cjoc202005028 shu

Advances in the Synthesis of Anislactone-Type Sesquiterpenes

Li Jian ^a,b ,
He Long ^a ,
Zhou Zhiqiang ^a ,
Zhen Yanxia ^a ,
Xie Weiqing ^a,,

a.
College of Chemistry & Pharmacy, Northwest A & F University, Shaanxi Key Laboratory of Natural Products Chemistry and Biology, Yangling, Shaanxi 712100
b.
College of Plant Protection, Northwest A & F University, Yangling, Shaanxi 712100

Corresponding author: Xie Weiqing, xiewq@nwafu.edu.cn
Received Date: 12 May 2020
Revised Date: 15 June 2020
Available Online: 24 June 2020
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 21722206, 21672171)National Natural Science Foundation of China 21722206National Natural Science Foundation of China 21672171

Figures(15)

The anislactone type sesquiterpenoids, (-)-merrilactones A-C and anislactones A-B, contain[5-5] bicyclic carbocyclic skeleton, two γ-butyrolactone structural units, featuring congested stereocenters and a high oxidation level. This type of natural products shows potent neurotrophic activity. Particularly, (-)-merrilactone A exhibits excellent neurotrophic activity even at lower concentration with potential for treating neurodisease such as Elzheimer disease. Due to their complex caged structures and excellent biologic profiles, the synthesis of aislactone-type sesquiterpenoids has attracted considerable attention from synthetic communities. This article summarizes the recent advances in the synthesis of this type of sesquiterpenoids.
- anislactone,
- merrilactone,
- sesquiterpenes,
- total synthesis
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