Citation: Lang Bo, Suleman Muhammad, Lu Ping, Wang Yanguang. Copper(I)-Promoted Trifluoromethylthiolation of 3-Diazoindolin-2-imines with AgSCF₃: Synthesis of 3-((Trifluoromethyl)thio)-2-aminoindoles[J]. Chinese Journal of Organic Chemistry, ;2020, 40(10): 3300-3306. doi: 10.6023/cjoc202005011 shu

Copper(I)-Promoted Trifluoromethylthiolation of 3-Diazoindolin-2-imines with AgSCF₃: Synthesis of 3-((Trifluoromethyl)thio)-2-aminoindoles

Department of Chemistry, Zhejiang University, Hangzhou 310027

Corresponding author: Lu Ping, pinglu@zju.edu.cn Wang Yanguang, orgwyg@zju.edu.cn
Received Date: 5 May 2020
Revised Date: 16 June 2020
Available Online: 30 July 2020
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 21772169, 21632003)the National Natural Science Foundation of China 21772169the National Natural Science Foundation of China 21632003

Figures(3)

A facile and efficient method for the synthesis of novel 3-((trifluoromethyl)thio)-2-aminoindoles through copper (I)-promoted trifluoromethylthiolation of 3-diazoindolin-2-imines with AgSCF₃ is reported. This methodology features a broad substrate scope of diazo compounds, economical copper(I) catalyst, readily available and stable diazo materials and trifluoromethylthiolating reagent, mild reaction conditions, short reaction time and water assisted higher yields.
- diazo compounds,
- metal carbenes,
- trifluoromethylthiolation,
- copper catalysis,
- indoles,
- heterocycles
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Copper(I)-Promoted Trifluoromethylthiolation of 3-Diazoindolin-2-imines with AgSCF3: Synthesis of 3-((Trifluoromethyl)thio)-2-aminoindoles

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Copper(I)-Promoted Trifluoromethylthiolation of 3-Diazoindolin-2-imines with AgSCF₃: Synthesis of 3-((Trifluoromethyl)thio)-2-aminoindoles