Citation: Luo Chunyan, Ma Wenjing, Lv Liang, Pang Huailin, Xiang Juncheng, Zhou Liqi, Yin Dulin, Liu Jiyong. Synthesis and Insecticidal Activity of Novel meta-Diamide Compounds Containing Cyclopropyl Group[J]. Chinese Journal of Organic Chemistry, ;2020, 40(9): 2963-2970. doi: 10.6023/cjoc202003025 shu

Synthesis and Insecticidal Activity of Novel meta-Diamide Compounds Containing Cyclopropyl Group

Luo Chunyan ^a ,
Ma Wenjing ^b ,
Lv Liang ^b ,
Pang Huailin ^b ,
Xiang Juncheng ^c ,
Zhou Liqi ^c ,
Yin Dulin ^a,, ,
Liu Jiyong ^b,,

a.
National & Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081
b.
CAC Shanghai International Trading Co., Ltd., Shanghai 200335
c.
Greentech Laboratory Co., Ltd., Shanghai 200335

Corresponding author: Yin Dulin, dulinyin@126.com Liu Jiyong, jiyong_liu@cacch.com
Received Date: 9 March 2020
Revised Date: 26 May 2020
Available Online: 15 July 2020

Figures(3)

To discover novel insecticide with improved activity, a series of meta-diamide compounds containing cyclopropyl moiety were synthesized on the principle of biologically active factor splicing. The structures of synthetic derivatives were characterized by ¹H NMR, ¹³C NMR and HRMS. Preliminary bioassay data showed that some of the title compounds exhibited good insecticidal activities against Plutella xylostella and Chilo suppressalis. Among them, the mortality of N-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-3-(N-(cyclopropylmethyl)benzamido)-2-fluorobenzamide (6d) and 3-(N-(cyclopropylmethyl)benzamido)-N-(2, 6-dibromo-4-(perfluoropropan-2-yl)phenyl)-2-fluorobenzamide (6e) was 100% against Plute-lla xylostella at 1 mg/L, and the mortality of compound 6d was 100% against Chilo suppressalis at 5 mg/L.
- synthesis,
- cyclopropyl,
- meta-diamide,
- inseticidal activity
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