Citation: Zheng Xixi, Liu Yunyun, Wan Jie-Ping. Advances in the Synthesis of N-Sulfonyl Amidines[J]. Chinese Journal of Organic Chemistry, ;2020, 40(7): 1891-1900. doi: 10.6023/cjoc202003019 shu

Advances in the Synthesis of N-Sulfonyl Amidines

College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022

Corresponding author: Liu Yunyun, chemliuyunyun@jxnu.edu.cn Wan Jie-Ping, wanjieping@jxnu.edu.cn
Received Date: 8 March 2020
Revised Date: 1 April 2020
Available Online: 11 April 2020
Fund Project: the National Natural Science Foundation of China 21861019Project supported by the National Natural Science Foundation of China (No. 21861019)

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Due to the special gem-nitrogen structure, amidines are important compounds in the synthesis of nitrogen contaning products. As a class of featured amidines, the N-sulfonyl amidines are key intermediates in a number of pivatol organic syntheses, and thus ocuppy significant position in modern organic synthesis. In this context, the research advances on the synthesis of N-sulfonyl amidines are herein reviewed. Based on the key reaction features, the introduction covers the synthetic methods of enamination by tertiary enamine oxidation, amide activation, akyne-azide-amine three-component reaction, enamine carbon-carbon bond functionalization and other related reactions. It is expected that this review will provide guidelines for the reasearch work in related areas.
- N-sulfonyl amidine,
- synthesis,
- amine oxidation,
- amide activation,
- three-component,
- enamine reaction
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