Citation: Wu Yan, Tian Xianzhi, Zhang Hailing, Chen Rui, Cao Tuanwu. Microwave-Assisted Iodine-Catalyzed 3-Selenocyanation of Indole for the Synthesis of 3-Selenocyanateindole Derivatives[J]. Chinese Journal of Organic Chemistry, ;2020, 40(5): 1384-1387. doi: 10.6023/cjoc201910003 shu

Microwave-Assisted Iodine-Catalyzed 3-Selenocyanation of Indole for the Synthesis of 3-Selenocyanateindole Derivatives

Chongqing Key Laboratory of Inorganic Special Functional Materials, College of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408000

Corresponding author: Cao Tuanwu, caotw2013@163.com
Received Date: 6 October 2019
Revised Date: 3 December 2019
Available Online: 3 January 2020
Fund Project: the Education Commission of Chongqing City KJQN201801404the Youth Talent Growth Plan Project of Yangtze Normal University 2018QNRC11the Basic and Frontier Research Project of Chongqing City Cstc2018jcyjAX0721Project supported by the Basic and Frontier Research Project of Chongqing City (Nos.Cstc2018jcyjAX0721, Cstc2016jcyjA0056), the Youth Talent Growth Plan Project of Yangtze Normal University (No.2018QNRC11), and the Education Commission of Chongqing City (No.KJQN201801404)the Basic and Frontier Research Project of Chongqing City Cstc2016jcyjA0056

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3-Selenocyanateindole derivatives have potential application in drug research due to their good biological activity. Until now, many methods for the synthesis of 3-selenocyanateindoles have been reported. However, drawbacks still exist, such as harsh reaction conditions, low yields and poor functional groups tolerance. A series of 3-selenocyanateindoles have been synthesized via the microwave-assisted 3-selenocyanation of indole derivatives by using 25 mol% iodine as catalyst, affording the corresponding products in good yields. Compared with the previous methods, this protocol has the advantages of rapid reaction, high yields and good atomic economy, providing an efficient route to 3-selenocyanateindole derivatives.
- microwave-assisted reaction,
- iodine-catalyzed selenocyanation,
- 3-selenocyanate iodines,
- iodine derivatives,
- potassium selenocyanate
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