Citation: Yang Sen, Zou Wenqian, Tao Min, Ma Tianyang, Liu Xinghai, Weng Jianquan, Tan Chengxia. Synthesis and Biological Activity of Diamide Compounds[J]. Chinese Journal of Organic Chemistry, ;2020, 40(3): 782-786. doi: 10.6023/cjoc201909023 shu

Synthesis and Biological Activity of Diamide Compounds

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014

Corresponding author: Tan Chengxia, tanchengxia@zjut.edu.cn
Received Date: 16 September 2019
Revised Date: 18 October 2019
Available Online: 7 November 2019
Fund Project: Project supported by the National Key R & D Program No.2017YFD0200507Project supported by the National Key R & D Program (No. 2017YFD0200507)

Figures(2)

In order to find pesticidal lead compounds with high activity, a series of novel diamide compounds were designed and synthesized by using metalaxyl as a leading compound, as well as the principle of active substructure combination. The structures of the target compounds were confirmed by ¹H NMR, ¹³C NMR and HRMS. The preliminary bioassay showed that compound 5j showed an 85% inhibition rate against Pseudoperoniospora cubensis at 50 mg/L, most of the target compounds had good insecticidal activity against Oriental armyworm at 500 mg/L, and compounds 5b, 5f, 5g, 5h, 5i and 5l have a mortality rate of 100% against Oriental armyworm. At 250 mg/L, the mortality rate of compounds 5f, 5h and 5l against Oriental armyworm was 50%.
- diamide compound,
- synthesize,
- biological activity
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