Citation: Wang Xun, Chen Su, Wu Yile, Wang Xiaoyu, Tang Guo, Liu Yan, Xu Pengxiang, Gao Xiang, Zhao Yufen. Intermolecular Ligand Exchange of Penta-oxy Phosphoranes: Potential Chemical Model for RNA Hydrolysis and Fusion[J]. Chinese Journal of Organic Chemistry, ;2019, 39(8): 2311-2316. doi: 10.6023/cjoc201905007 shu

Intermolecular Ligand Exchange of Penta-oxy Phosphoranes: Potential Chemical Model for RNA Hydrolysis and Fusion

Wang Xun ^a ,
Chen Su ^a ,
Wu Yile ^a ,
Wang Xiaoyu ^b ,
Tang Guo ^a ,
Liu Yan ^a ,
Xu Pengxiang ^a ,
Gao Xiang ^b,, ,
Zhao Yufen ^a,b,c,,

a.
Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005
b.
School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102
c.
Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211

Corresponding author: Gao Xiang, xgao@xmu.edu.cn Zhao Yufen, yfzhao@xmu.edu.cn
Received Date: 20 March 2019
Revised Date: 17 April 2019
Available Online: 26 August 2019
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 21778042, 41876072, 21772163, 41576081), the Xiamen Southern Oceanographic Center (No. 17GYY002NF02), and the Fundamental Research Funds for the Central Universities (No. 20720170069)the National Natural Science Foundation of China 21772163the National Natural Science Foundation of China 21778042the National Natural Science Foundation of China 41876072the Fundamental Research Funds for the Central Universities 20720170069the National Natural Science Foundation of China 41576081the Xiamen Southern Oceanographic Center 17GYY002NF02

Figures(7)

Penta-coordinated phosphoranes (ab₂) with a five-member cycle and three ligands would simultaneously exchange with themselves under base catalysis to form three different penta-oxy phosphoranes with all the combinatorial ligands referred as a₃, b₃, and a₂b. If we consider a₃ and b₃ as parents, the products obtained from exchange, namely a₂b and ab₂, could be regarded as the offspring of the first generation, leading to the diversified chemical structures. Thus, these fascinating reactions could be considered as a promising chemical model for studying the unique chemistry of possible penta-coordinated phosphorus intermediates in the process of RNA self-splicing, hydrolysis and fusion for gene transcription and biological information storage.
- phosphorus chemistry,
- penta-oxy phosphorane,
- ligand exchange,
- organic chemical model
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