Citation: Wang Zhen, Zhang Ling, Zhang Fugeng, Wang Bin. Synthesis of β-Carbolines through Tetra-n-butylammonium Bromide-Mediated Cycloaromatization Reaction of N-Methylaniline with Tryptophan Derivatives[J]. Chinese Journal of Organic Chemistry, ;2019, 39(8): 2323-2327. doi: 10.6023/cjoc201903077 shu

Synthesis of β-Carbolines through Tetra-n-butylammonium Bromide-Mediated Cycloaromatization Reaction of N-Methylaniline with Tryptophan Derivatives

Wang Zhen ^a,† ,
Zhang Ling ^b,† ,
Zhang Fugeng ^b,, ,
Wang Bin ^a,,

a.
College of Pharmacy, Nankai University, Tianjin 300353
b.
Department of Pharmacy, Affiliated Huanhu Hospital of Nankai University, Tianjin 300350

Corresponding author: Zhang Fugeng, clare2006@163.com Wang Bin, wangbin@nankai.edu.cn

Received Date: 30 March 2019
Revised Date: 16 May 2019
Available Online: 3 August 2019
Fund Project: the National Natural Science Foundation of China 21172120Project supported by the National Natural Science Foundation of China ((Nos. 21172120, 21472093)the National Natural Science Foundation of China 21472093

Figures(2)

A mild and efficient ⁿBu₄NBr-mediated oxidative cycloaromatization to prepare β-carbolines from readily available tryptophans and N-methylaniline is described. The present metal free protocol is complementary to the existing methods for the synthesis of aromatic β-carbolines.
- β-carboline,
- tetra-n-butylammonium bromide,
- N-methylaniline,
- cycloaromatization
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