Citation: Cheng Cheng, Sun Xiaobin, Miao Zhiwei. Progress in Synthesis of Eight-Membered Cyclic Ethers[J]. Chinese Journal of Organic Chemistry, ;2019, 39(8): 2148-2156. doi: 10.6023/cjoc201903068 shu

Progress in Synthesis of Eight-Membered Cyclic Ethers

a.
Research Institute of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071
b.
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071

Corresponding author: Miao Zhiwei, miaozhiwei@nankai.edu.cn
Received Date: 28 March 2019
Revised Date: 29 April 2019
Available Online: 15 August 2019
Fund Project: Project supported by the National Key Research and Development Program of China 2016YFD0201200Project supported by the National Key Research and Development Program of China (No. 2016YFD0201200) and the Fundamental Research Funds for the Central Universities, Nankai University (No. 63191205)the Fundamental Research Funds for the Central Universities, Nankai University 63191205

Figures(21)

Eight membered cyclic ether compounds are common structural motifs in natural products and bioactive molecules. The efficient synthesis of eight membered ethers has attracted wide attention for organic chemists. Compared with five-to seven-membered cyclic ethers, the synthesis of eight membered cyclic ethers is more challenging. In this paper, the synthetic methods for eight membered cyclic ethers by transition metal catalysis, ring expansion, retro-Claisen rearrangement, ring-closing metathesis, intramolecular amide enol alkylation and organic catalyzed tandem cyclization are reviewed.
- eight-membered cyclic ethers,
- synthesis method,
- asymmetric synthesis
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