Citation: Yang Shengbiao, Li Yan, Zhang Qian. Copper-Catalyzed Cyclization of 1-Aryl-1-cycloalcohols and 1, 3-Dicarbonyl Compounds: Synthesis of Cycloalkane-Fused Dihydrofuran Derivatives[J]. Chinese Journal of Organic Chemistry, ;2019, 39(8): 2226-2234. doi: 10.6023/cjoc201903040 shu

Copper-Catalyzed Cyclization of 1-Aryl-1-cycloalcohols and 1, 3-Dicarbonyl Compounds: Synthesis of Cycloalkane-Fused Dihydrofuran Derivatives

Yang Shengbiao ^a ,
Li Yan ^a,, ,
Zhang Qian ^a,b,,

a.
Department of Chemistry, Northeast Normal University, Changchun 130024
b.
State Key Laboratory of Organometallic Chemistry, Shang Hai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Corresponding author: Li Yan, liy078@nenu.edu.cn Zhang Qian, zhangq651@nenu.edu.cn
Received Date: 21 March 2019
Revised Date: 16 May 2019
Available Online: 21 August 2019
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21831002) and Ten Thousand Talents Programthe National Natural Science Foundation of China 21831002

Figures(5)

A novel method of copper-catalyzed cyclization of 1-aryl-1-cycloalcohols and 1, 3-dicarbonyl compounds has been developed, affording various cycloalkane-fused dihydrofurans in moderate to excellent yields. This transformation proceeds under mild conditions and with a good tolerance of functional groups. The mechanistic investigation revealed that the reaction involved radical intermediates.
- cyclization,
- cycloalcohol,
- 1, 3-dicarbonyl compound,
- dihydrofuran
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