Citation: Li Xiaojun, Zhang Wanbin, Gao Shuanhu. Total Synthesis of Complex Natural Products: Combination of Chemical Synthesis and Biosynthesis Strategies[J]. Chinese Journal of Organic Chemistry, ;2018, 38(9): 2185-2198. doi: 10.6023/cjoc201806019 shu

Total Synthesis of Complex Natural Products: Combination of Chemical Synthesis and Biosynthesis Strategies

Li Xiaojun ^a ,
Zhang Wanbin ^c,, ,
Gao Shuanhu ^a,b,,

a.
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, Shanghai 200062
b.
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062
c.
School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, Shanghai 200240

Corresponding author: Zhang Wanbin, wanbin@sjtu.edu.cn Gao Shuanhu, shgao@chem.ecnu.edu.cn
Received Date: 14 June 2018
Revised Date: 9 July 2018
Available Online: 16 September 2018
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21772044), the National Young Top-Notch Talent Support Program of Shanghai Academic/Technology Research Leader (No. 18XD1401500) and the Fundamental Research Funds for the Central Universitiesthe National Young Top-Notch Talent Support Program of Shanghai Academic/Technology Research Leader 18XD1401500the National Natural Science Foundation of China 21772044

Figures(18)

Total synthesis of natural products is one of the most important field in organic chemistry. Natural products and derivatives, containing complex structures and potential biological activities, are also indispensable sources of drug discovery. The total synthesis of natural products through the combination of chemical synthesis and biosynthesis strategies is reviewed. The main content includes the chemical and biosynthetic studies of artemisinin, spinosyn A, myceliothernophin E and equisetin.
- total synthesis of natural products,
- chemical synthesis,
- biosynthesis
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沈阳化工大学材料科学与工程学院沈阳 110142