Citation: Bai Feicheng, Hu Deqing, Liu Yunyun, Wei Li. One-Pot and Multicomponent Synthesis of N-Substituted-4-hydroxyl-2-pyridones[J]. Chinese Journal of Organic Chemistry, ;2018, 38(8): 2054-2059. doi: 10.6023/cjoc201801015 shu

One-Pot and Multicomponent Synthesis of N-Substituted-4-hydroxyl-2-pyridones

College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022

Corresponding author: Wei Li, wl@jxnu.edu.cn
Received Date: 8 January 2018
Revised Date: 21 March 2018
Available Online: 27 August 2018
Fund Project: the Department of Education of Jiangxi Province GJJ160328Project supported by the Department of Education of Jiangxi Province (No. GJJ160328) and the Doctoral Start-up Fund of Jiangxi Normal University

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A series of 4-hydroxyl-2-pyridone derivatives were synthesized via a one-pot and multicomponent reaction of dimethyl 3-oxopentanedioate, N, N-dimethylformamide dimethyl acetal (DMF-DMA) and primary amine in aliphatic alcohol by using L-proline as catalyst. The structures of these compounds were confirmed by NMR and HRMS. This work provides a convenient method for construction of pyridones with the advantages of operation simplicity, free of isolating intermediates etc. Moreover, the participation of solvent in the reaction enriched the diversity of 5-substitution in the pyridone backbone.
- 4-hydroxyl-2-pyridone,
- multicomponent reaction,
- dimethyl 3-oxopentanedioate,
- one-pot synthesis
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