Citation: Huang Jiapian, Gu Qing, You Shuli. Synthesis of Planar Chiral Ferrocenes via Transition-Metal-Catalyzed Direct C-H Bond Functionalization[J]. Chinese Journal of Organic Chemistry, ;2018, 38(1): 51-61. doi: 10.6023/cjoc201708030 shu

Synthesis of Planar Chiral Ferrocenes via Transition-Metal-Catalyzed Direct C-H Bond Functionalization

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Corresponding author: Gu Qing, qinggu@sioc.ac.cn You Shuli, slyou@sioc.ac.cn
Received Date: 15 August 2017
Revised Date: 13 September 2017
Available Online: 15 January 2017
Fund Project: the National Natural Science Foundation of China 21572250Project supported by the National Key R&D Program of China (No. 2016YFA0202900), the National Basic Research Program of China (973 Program, No. 2015CB856600), the National Natural Science Foundation of China (Nos. 21332009, 21421091, 21572250), and the Chinese Academy Sciences (Nos. XDB20000000, QYZDY-SSW-SLH012)the National Basic Research Program of China 2015CB856600the Chinese Academy Sciences XDB20000000the National Key R&D Program of China 2016YFA0202900the Chinese Academy Sciences QYZDY-SSW-SLH012the National Basic Research Program of China 973 Programthe National Natural Science Foundation of China 21421091the National Natural Science Foundation of China 21332009

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Ferrocenes bearing planar chirality have been demonstrated to be highly efficient ligands or catalysts in asymmetric catalysis. In view of their atom and step economies, direct asymmetric C—H bond functionalization is the most concise and powerful method for the construction of planar chiral ferrocenes compared with traditional approaches. This review summarizes recent progress on the development of novel methods to synthesize planar chiral compounds via transition-metal (Cu-, Pd-, Ir-, Rh-, Au-, Pt-) catalyzed asymmetric C—H bond functionalization. Preparation of a variety of new planar chiral ferrocene-based catalysts and ligands by utilizing these methods and their application in catalytic asymmetric reactions are also discussed.
- transition metal catalysis,
- asymmetric catalysis,
- direct C-H bond functionalization,
- planar chirality,
- ferrocene
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