Citation: Liao Yun, Zhu Lei, Yu Yinghua, Chen Gui, Huang Xueliang. N-Heterocycle Synthesis via Gold-Catalyzed Intermolecular Nitrene Transfer Reactions of Alkynes[J]. Chinese Journal of Organic Chemistry, ;2017, 37(11): 2785-2799. doi: 10.6023/cjoc201708021 shu

N-Heterocycle Synthesis via Gold-Catalyzed Intermolecular Nitrene Transfer Reactions of Alkynes

Liao Yun ^a,b ,
Zhu Lei ^b ,
Yu Yinghua ^b ,
Chen Gui ^b,, ,
Huang Xueliang ^b,,

a.
College of Chemistry, Fuzhou University, Fuzhou 350116
b.
Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002

Corresponding author: Chen Gui, chengui@fjirsm.ac.cn Huang Xueliang, huangxl@fjirsm.ac.cn
Received Date: 11 August 2017
Revised Date: 8 September 2017
Available Online: 19 November 2017
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 21402197, 21502190), and the Natural Science Foundation of Fujian Province (No. 2017J01031)the National Natural Science Foundation of China 21402197the National Natural Science Foundation of China 21502190the Natural Science Foundation of Fujian Province 2017J01031

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N-Heterocyclic rings are versatile structural units that widely dispersed in a variety of natural products, biological active species, and photoelectric materials. They are also useful building blocks in synthetic community. This review mainly focused on recent progress on gold-catalyzed intermolecular nitrene transfer reactions with alkynes. This strategy complements the toolbox for the synthesis of multisubstituted N-heterocyclic compounds. Mechanistically, activated by a suitable gold catalyst, the specific alkyne could react with a nitrene precursor, providing the final N-heterocyclic compounds in highly efficient manner.
- gold-catalysis,
- ynamide,
- nitrene precursor,
- N-heterocycle,
- α-imino-gold-carbene
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