Citation: Wang Yufeng, Yang Yajie, Huang Ling, Jie Kun, Guo Shengmei, Cai Hua. Iodine Catalyzed Kabachnik-Fields Reaction of Trialkyl Phosphites: Facile Access to Benzoxazine Containing Phosphorus[J]. Chinese Journal of Organic Chemistry, ;2017, 37(12): 3220-3228. doi: 10.6023/cjoc201705023 shu

Iodine Catalyzed Kabachnik-Fields Reaction of Trialkyl Phosphites: Facile Access to Benzoxazine Containing Phosphorus

Wang Yufeng ^a,, ,
Yang Yajie ^b,, ,
Huang Ling ^a ,
Jie Kun ^a ,
Guo Shengmei ^a,, ,
Cai Hua ^a,,

a.
College of Chemistry, Nanchang University, Nanchang 330031
b.
The First College of Clinical Medicine, Nanchang University, Nanchang 330031

Corresponding author: Wang Yufeng, smguo@ncu.edu.cn Yang Yajie, Guo Shengmei, Cai Hua, caihu@ncu.edu.cn
Received Date: 16 May 2017
Revised Date: 13 July 2017
Available Online: 16 December 2017
Fund Project: the National Program on Key Basic Research Project 973 Program, No. 2012CBA01204the Natural Science Foundation of Jiangxi Province 20151BAB213007the National Natural Science Foundation of China 21302084Project supported by the National Program on Key Basic Research Project (973 Program, No. 2012CBA01204), the National Natural Science Foundation of China (No. 21302084) and the Natural Science Foundation of Jiangxi Province (No. 20151BAB213007)

Figures(3)

Iodine-catalyzed Kabachnik-Fields reaction with trialkyl phosphites for the synthesis of α-amino phosphates was developed. This transformation completes rapidly at 40℃, and is well tolerated with a range of amines and phosphites. Moreover, the products afforded by salicyl aldehydes with trialkyl phosphites could efficiently convert to benzoxazines containing phosphate under mild conditions, which provide a new precursor of new phenolic resin
- trialkyl phosphite,
- benzoxazineis,
- Kabachnik-Fields reaction,
- iodine
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