Citation: Liu Xinlei, Zhao Yu, Wang Weiwei, Wang Ming'an, Zhou Ligang. Recent Progress of Natural Product Spirobisnaphthalenes[J]. Chinese Journal of Organic Chemistry, ;2017, 37(11): 2883-2894. doi: 10.6023/cjoc201705020 shu

Recent Progress of Natural Product Spirobisnaphthalenes

a.
Department of Applied Chemistry, China Agricultural University, Beijing 100193
b.
Department of Plant Pathology, China Agricultural University, Beijing 100193

Corresponding author: Wang Ming'an, wangma@cau.edu.cn
Received Date: 15 May 2017
Revised Date: 21 June 2017
Available Online: 7 November 2017
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21172254)the National Natural Science Foundation of China 21172254

Figures(13)

Spirobisnaphthalenes (spirodioxynaphthalenes) are one class of highly oxidized natural products in which two naphthalenes are connected by spiroketal or binaphthalene spiroether. Because of their novel and complex structures, multi-chiral centers and broad bioactivities, synthetic chemists paid a lot of attention to this type of compounds in recent years. The new research progresses of spirobisnaphthalene natural products after 2010 are reviewed based on the results in our laboratory, including 62 new chemical structures, total synthesis and modification, biosynthetic pathway, bioactivities and structure-activity relationships of spirobisnaphthalenes. The objective is to promote the creation of novel drugs and agrochemicals by lead discovery and modification of natural products in China.
- spirobisnaphthalene,
- spiroketal,
- natural product,
- synthesis,
- bioactivity
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