Citation: Wu Yuqin, Yu Liangyun, Zhang Qi, Li Lidong. Synthesis of Dihydrophenanthridines by Palladium-Catalyzed[2+2+2] Cyclization Reactions[J]. Chinese Journal of Organic Chemistry, ;2017, 37(9): 2336-2342. doi: 10.6023/cjoc201703004 shu

Synthesis of Dihydrophenanthridines by Palladium-Catalyzed[2+2+2] Cyclization Reactions

School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051

Corresponding author: Li Lidong, ld-l@163.com
Received Date: 2 March 2017
Revised Date: 30 March 2017
Available Online: 10 September 2017
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21272005)National Natural Science Foundation of China 21272005

Figures(3)

Phenanthridines are important core structures found in a variety of natural products and other biologically important molecules with a wide range of biological activities and applications, including antibacterial and anticancer agents. A practical and efficient domino method for the preparation of dihydrophenanthridines from diynes and aryl halides is developed via palladium-catalyzed[2+2+2] cycloaddition reactions. All new products were fully characterized by IR, ¹H NMR, ¹³C NMR and high-resolution mass spectrometry. The molecular structure of 1-(7, 12-diphenyl-5-tosyl-5, 6-dihydrobenzo[j]-phenanthridin-10-yl)ethan-1-one (3b) was confirmed by using single-crystal X-ray analyses.
- palladium-catalyzed,
- synthesis,
- C-C coupling,
- dihydrophenanthridine
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