Citation: Lin Wei, Zheng Yongxiang, Huang Zhibin, Shi Daqing. Rapid and Efficient Ultrasound-Assisted Method for the Synthesis of 2-Thioxo-2H-thiopyran and 2-Amino-6-thioxodihydropyridine Derivatives[J]. Chinese Journal of Organic Chemistry, ;2017, 37(2): 508-513. doi: 10.6023/cjoc201608017 shu

Rapid and Efficient Ultrasound-Assisted Method for the Synthesis of 2-Thioxo-2H-thiopyran and 2-Amino-6-thioxodihydropyridine Derivatives

a.
School of Chemistry and Environmental Engineering, Jiangsu Technology of University, Changzhou 213001
b.
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123

Corresponding author: Shi Daqing, dqshi@suda.edu.cn
Received Date: 22 August 2016
Revised Date: 2 November 2016

Fund Project: the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions 15KJA150006the National Natural Science Foundation of China 21502074

Figures(1)

A rapid and efficient ultrasound-assisted method for the synthesis of 2-thioxo-2H-thiopyran and 2-amino-6-thioxodihydropyridine derivatives by the reaction of 2-(1-phenylethylidene) malononitrile and carbon disulfide or isothiocy-anatobenzene catalyzed by NaOH has been developed. This protocol has the advantages of simple operation, short reaction times, high yields, and environmental friendliness. The structures of all the products were characterized by ¹H NMR, ¹³C NMR, IR and MS techniques. The reported method is the efficient approach for the synthesis of 2-thioxo-2H-thiopyran and 2-amino-6-thi-oxodihydropyridine derivatives.
- 2-thioxo-2H-thiopyran,
- 2-amino-6-thioxodihydropyridine,
- ultrasound-assisted,
- synthesis
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