Citation: . Efficient One-Pot Synthesis of Diphenyl-2,4-dioxa-8,10-diazaspiro-[5.5]undecane-1,5,9-trione Derivatives under Solvent-Free and Catalyst-Free[J]. Chinese Journal of Organic Chemistry, ;2016, 36(8): 1948-1953. doi: 10.6023/cjoc201601032 shu

Efficient One-Pot Synthesis of Diphenyl-2,4-dioxa-8,10-diazaspiro-[5.5]undecane-1,5,9-trione Derivatives under Solvent-Free and Catalyst-Free

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Corresponding author: , gotoxzh@163.com , gotoxzh@163.com
Received Date: 23 January 2016
Revised Date: 22 March 2016

Fund Project: the Graduate Innovation Foundation of Jiangxi Province No.YC2015-B023the National Natural Science Foundation of China Nos. 20566004

Figures(2)

Twelve kinds of diphenyl-2,4-dioxa-8,10-diazaspiro[5.5]undecane-1,5,9-trione derivatives were synthesized by the three-component one-pot reaction of aromatic aldehydes with urea and 2,2-butylidene-1,3-dioxane-4,6-dione or 2,2-pentyli- dene-1,3-dioxane-4,6-dione under solvent-free and catalyst-free. The yields ranged from 49% to 63%. Its advantages were no solvent pollution and mild reaction conditions. Furthermore, a proposed reaction mechanism for this condensation reaction was speculated and the relationship between reaction speed and substituent groups was also described. All the compounds synthesized were confirmed by ¹H NMR, ¹³C NMR, ESI-MS and IR techniques.
- three-component reaction,
- diphenyl-2,4-dioxa-8,10-diazaspiro[5.5]undecane-1,5,9-trione derivatives,
- solvent- free,
- catalyst-free
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