Citation: Liu Ming, Liu Yang, Liu Ailin, Zhang Dongkai, Chen Minggui, Wu Changchun, Hua Xuewen, Zhou Sha, Li Zhengming. Synthesis and Bioactivities of Novel Coumarin Derivatives Containing Sulfinic Esters or Sulfinamide Moiety[J]. Chinese Journal of Organic Chemistry, ;2016, 36(7): 1653-1661. doi: 10.6023/cjoc201601011 shu

Synthesis and Bioactivities of Novel Coumarin Derivatives Containing Sulfinic Esters or Sulfinamide Moiety

Liu Ming ^a ,
Liu Yang ^a ,
Liu Ailin ^b ,
Zhang Dongkai ^a ,
Chen Minggui ^a ,
Wu Changchun ^a ,
Hua Xuewen ^a ,
Zhou Sha ^a ,
Li Zhengming ^a,*,,

a.
State Key Laboratory of Elemento-organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071
b.
Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050

Corresponding author: Li Zhengming, nkzml@vip.163.com
Received Date: 11 January 2016
Revised Date: 22 February 2016

Fund Project: the “111” Project of Ministry of Education of China No. B06005

Figures(2)

A series of novel coumarin derivatives containing sulfinic esters or sulfonamide were designed and synthesized. Their structures were characterized by ¹H NMR, ¹³C NMR and elemental analysis. The preliminary bioassays indicated that several target compounds exhibited good in vitro antitumor activities on A549 (up to 67.82%), Bel7402 (up to 58.47%) and HCT-8 (up to 74.80%) at 5.0 mg/L and moderate antifungal activities on Physalospora piricola (up to 82.0 %) at 50 mg/L. The structure-activity relationship of these target compounds was discussed accordingly.
- coumarin,
- sulfinic esters,
- sulfinamide,
- anticancer activity,
- antifungal activity
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