Citation: Chen Cheng, Luo Zhuoma, Yang Hongjun, Feng Yuchuan. A Novel Synthetic Route for Berberine Chloride[J]. Chinese Journal of Organic Chemistry, ;2016, 36(6): 1426-1430. doi: 10.6023/cjoc201511028 shu

A Novel Synthetic Route for Berberine Chloride

1.
College of Chemistry & Environment Protection Engineering, Southwest University for Nationalities, Chengdu 610041

Corresponding author: Yang Hongjun, yanghj@swun.cn Feng Yuchuan, cdfycfeng1219@163.com
Received Date: 16 November 2015
Revised Date: 2 January 2016

Fund Project: and the Research Projects Sichuan Provincial Department of Education No.15ZB0487Project supported by the Fundamental Research Funds for the Central Universities, Southwest University for Nationalities No.2014NZYQN21

Figures(1)

Berberine chloride was synthesized starting from pyrocatechol in overall 13.6% yield. The key steps include a Hofmann rearrangement, chloromethylation, nucleophilic substitution, hydrolysis, decarboxylation, and cyclization. All of intermediates were determined by ¹H NMR, ¹³C NMR, MS techniques.
- pyrocatechol,
- 3,4-methylenedioxyphenylethylamine,
- berberine chloride,
- synthesis
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沈阳化工大学材料科学与工程学院沈阳 110142