Citation: Rao Honghong, Quan Zhengjun, Bai Lin, Ye Helin. Progress on the Synthesis of Enantiomerically Pure 3,4-Dihydropyrimidin-2-one Derivatives[J]. Chinese Journal of Organic Chemistry, ;2016, 36(2): 283-296. doi: 10.6023/cjoc201507001 shu

Progress on the Synthesis of Enantiomerically Pure 3,4-Dihydropyrimidin-2-one Derivatives

1.
a School of Chemistry and Environmental Science, Lanzhou City University, Lanzhou 730070;
2.
b College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Corresponding author: Rao Honghong,
Received Date: 1 July 2015
Available Online: 14 September 2015
Fund Project: 国家自然科学基金(Nos. 21265009, 21362032)资助项目. (Nos. 21265009, 21362032)

3,4-Dihydropyrimidinethiones are chiral molecules, however, only racemic products are isolated in the most reported Biginelli reactions. It has been proved that the absolute configuration of the C(4) stereogenic center has significant influence on the biological activity. The development in the accessing of optically active 3,4-dihydropyrimidinethiones focusing on the recent advances in the asymmetric catalytic Biginelli reactions is summarized.
- enantiomerically pure 3,4-dihydropyrimidin-2-(1H)-ones,
- asymmetric catalysis,
- Biginelli reaction,
- multicomponent reactions
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