Citation: Zhang Shuo, Hou Zitong, Song Zihe, Su Xiaofeng, Wang Feng, Yu Yitao, Peng Dan, Cui Shiqi, Liu Yifan, Wang Jiarui, Song Jianjun. Zn/Ni Bimetallic Relay Catalysis: One Pot Intramolecular Cycloisomerization/Intermolecular Amidoalkylation Reaction toward Oxazole Derivatives[J]. Acta Chimica Sinica, ;2019, 77(11): 1168-1172. doi: 10.6023/A19080303 shu

Zn/Ni Bimetallic Relay Catalysis: One Pot Intramolecular Cycloisomerization/Intermolecular Amidoalkylation Reaction toward Oxazole Derivatives

Zhang Shuo ^a ,
Hou Zitong ^b ,
Song Zihe ^b ,
Su Xiaofeng ^a ,
Wang Feng ^a ,
Yu Yitao ^a ,
Peng Dan ^a,, ,
Cui Shiqi ^b ,
Liu Yifan ^b ,
Wang Jiarui ^c ,
Song Jianjun ^b,,

a.
Shandong Provincial Key Laboratory for Special Silicone-Containing Materials, Advanced Materials Institute, Qilu University of Technology(Shandong Academy of Sciences), Jinan 250014, China
b.
Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology(Shandong Academy of Sciences), Jinan 250353, China
c.
College of Food Science and Engineering, Shandong Agricultural University, Taian 271018, China

Corresponding author: Peng Dan, lonarpeng@aliyun.com Song Jianjun, songjianjun@qlu.edu.cn
Received Date: 16 August 2019
Available Online: 14 November 2019
Fund Project: Project supported by the Shandong Provincial Natural Science Foundation (No. ZR2017BB033), the Youth Science Funds of Shandong Academy of Sciences (No. 2018QN0030) and the National Natural Science Foundation of China (No. 51503118)the Shandong Provincial Natural Science Foundation ZR2017BB033the Youth Science Funds of Shandong Academy of Sciences 2018QN0030the National Natural Science Foundation of China 51503118

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Oxazole derivatives are widely found in natural products and pharmaceuticals with impressive biological properties, tremendous efforts have been devoted to the development of new methodologies and strategies to construct the oxazole rings. However, most of these reactions require harsh reaction conditions, limiting the wide application of these classical oxazole synthetic methods in organic synthesis. N-Acyliminium ions represent important electron deficient carbocations intermediates in organic synthesis because they provide various biologically important natural and unnatural products via C-C and C-heteroatom bondforming methodologies using an inter-or intramolecular path. The removal of a good leaving group at the α-position of amides or lactams usually generates N-acyliminium ions, which act as more electron-deficient carbocations toward nucleophiles. In this paper, a novel tandem metal relay catalytic system of Zn/Ni has been successfully developed. By using this unprecedented Zn(OTf)₂/Ni(ClO₄)₂·6H₂O bimetallic relay catalytic system, a variety of oxazole derivatives were obtained from easily available N-(propargyl)-arylamides and various γ-hydroxy lactams through intramolecular cycloisomerization/intermolecular amidoalkylation under mild conditions. The first step of the one-pot procedure is that Zn(OTf)₂ acts as a π acid to activate the triple bond of N-(propargyl)-arylamides, and a subsequent intramolecular 5-exo-dig cyclization forms the oxazoline intermediate. Separately, Ni(ClO₄)₂·6H₂O acts as Lewis acid to activate and facilitate the departure of 3-hydroxyl group to form the electrophilic acyliminium ions, which then in an intermolecular reaction is transformed to the oxazole derivatives in good to excellent yield. Control experiments in the optimization section disclose the fact that Zn(OTf)₂ and Ni(ClO₄)₂·6H₂O are both indispensable for this intramolecular cycloisomerization/intermolecular amidoalkylation reaction. Generally, the synthetic reactions run under air atmosphere by heating all the substrates and reagents in one-pot at 100℃. The N-(propargyl)-arylamide containing different types of electron-donating substituents, different electron-rich aromatic rings and different electron-withdrawing substituents can react with 3-hydroxy-2-benzyl-isoindolin-1-one to give the corresponding oxazole derivatives. In contrast, the propargyl amide containing an electron withdrawing group has a lower yield than the one using other propargyl amide, because the activity of the oxazoline intermediate obtained by the propargyl amide containing an electron withdrawing group is lower. 3-Hydroxy-2-phenylisoindoline-1-one, 3-hydroxy-2-phenylmethylisoindoline-1-one and 3-hydroxy-2-phenylethylisoindoline-1-one have also been found applicable to this reaction. The present method benefits from the distinctive features of simple reaction conditions, high atom economy and broad substrate tolerance. It is of great significance for the synthesis of oxazole derivatives and the formation of acyliminium ions.
- relay catalysis,
- cycloisomerization,
- acyliminium ion,
- amidoalkylation reaction,
- oxazole derivatives
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