Citation: DING Lan-Lan, LUAN Li-Qiang, SHI Jia-Wei, LIU Wei. Phthalocyanine Based Photosensitizers for Photodynamic Therapy[J]. Chinese Journal of Inorganic Chemistry, ;2013, 29(8): 1591-1598. doi: 10.3969/j.issn.1001-4861.2013.00.311 shu

Phthalocyanine Based Photosensitizers for Photodynamic Therapy

  • Received Date: 26 February 2013
    Available Online: 20 June 2013

    Fund Project: 国家自然科学基金(No.21071090) (No.21071090)山东大学自主创新基金(No.2012JC013)资助项目。 (No.2012JC013)

  • Photodynamic therapy (PDT) is a clinically approved procedure. Due to its minimal normal tissue toxicity, negligible side effects and high selectivity, it has emerged as an efficient treatment method for many kinds of cancers. Recently, significant effort has been devoted to enhance its selectivity and phototoxicity toward malignant tissues. This review summarizes the recent research of photosensitizers, especially focuses on the progress of the third generation photosensitizers based on phthalocyanines.
  • 加载中
    1. [1]

      [1] Dolmans D, Fukumura D, Jain R. Nat. Rev. Cancer, 2003,3 (5):380-387

    2. [2]

      [2] Agostinis P, Berg K, Cengel K, et al. CA Cancer J Clin, 2011,61(4):250-281

    3. [3]

      [3] Dougherty T, Gomer C, Henderson B, et al. J. Natl. Cancer Inst., 1998,90(12):889-905

    4. [4]

      [4] GAO Yuan(高源), QIAO Guang-Ming(乔光明), LI Na(李娜), et al. Chinese J. Anal. Chem.(Fenxi Huaxue), 2011,39(12): 1926-1931

    5. [5]

      [5] Foote C. Science, 1968,162(3857):963-970

    6. [6]

      [6] Moan J, Berg K. Photochem. Photobiol., 1991,53(4):549-553

    7. [7]

      [7] Juzeniene A, Nielsen K, Moan J. J. Environ. Pathol. Toxicol. Oncol., 2006,25(1-2):7-28

    8. [8]

      [8] Brancaleon L, Moseley H. Lasers Med. Sci., 2002,17(3):173-186

    9. [9]

      [9] Juzeniene A, Juzenas P, Ma L, et al. Lasers Med. Sci., 2004, 19(3):139-149

    10. [10]

      [10] Sharman W, Allen C, van Lier J. Drug Discov. Today, 1999, 4(11):507-517

    11. [11]

      [11] WANG Ling-Yun(汪凌云), CAO De-Rong(曹德榕). Chin. J. Org. Chem.(Youji Huaxue), 2012,32:2248-2264

    12. [12]

      [12] ZHU Jing(朱菁), SHI Hong-Min(施虹敏), ZHANG Hui-Guo (张慧国). Chinese J. Lasers(Zhongguo Jiguang), 2000,27(1): 95-96

    13. [13]

      [13] JIN Xiao-Min(金晓敏), WU Jian(吴健). Chin J. Med. Chem. (Zhongguo Yaowu Huaxue Zazhi), 2002,12(1):52-56

    14. [14]

      [14] Pandeyi R K, Potter W R, Meunier I, et al. Photochem. Photobiol., 1995,62(4):764-768

    15. [15]

      [15] LIU Yan-Yan(刘岩岩), WANG Xue-Song(王雪松), ZHANG Bao-Wen(张宝文). Prog. Chem.(Huaxue Jinzhan), 2008,20 (9):1345-1352

    16. [16]

      [16] Luan L, Ding L, Zhang W, et al. Bioorg. Med. Chem. Lett., 2013,23(13):3775-3779

    17. [17]

      [17] Uslan C, Sesalan B, Durmus M. J. Photochem. Photobiol. A. Chem., 2012,235:56-64

    18. [18]

      [18] Liu W, Jensen T, Fronczek F, et al. J. Med. Chem., 2005,48 (4):1033-1041

    19. [19]

      [19] Luan L, Chen J, Ding L, et al. Chem. Lett., 2012,41:1012-1014

    20. [20]

      [20] WU Li-Rong(吴丽荣), HUANG Li-Ying(黄丽英), XU Hui (许慧). U. Chem.(Daxue Huaxue), 2010,25(4):1-10

    21. [21]

      [21] LIU Li-Zhen(刘丽珍), ZHENG Si-Ning(郑思宁), PENG Yi-Ru(彭亦如), et al. J. Mol. Sci.(Fenzi Kexue Xuebao), 2005, 21(5):56-62

    22. [22]

      [22] HUANG Yan(黄焱), XU Guo-Xing(徐国兴), PENG Yi-Ru(彭亦如). Applied Laser(Yingyong Jiguang), 2010,30(6):518-524

    23. [23]

      [23] HUANG Jian-Dong(黄剑东), LIU Feng-Ran(刘丰冉), CHEN Yan-Mei(陈燕梅), et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 2006,22(3):435-442

    24. [24]

      [24] NIU Li-Hong(牛丽红), LI Zhong-Yu(李忠玉), CHEN Zi-Hui (陈子辉), et al. Chemistry(Huaxue Tongbao), 2009,72(3):251-257

    25. [25]

      [25] HUANG Jin-Ling(黄金陵), CHEN Nai-Sheng(陈耐生), WANG Jun-Dong(王俊东), et al. CN Patent, CN1593424. 2005-03-16.

    26. [26]

      [26] Derycke A, de Witte P. Adv. Drug Deliv. Rev., 2004,56(1): 17-30

    27. [27]

      [27] Bechet D, Couleaud P, Frochot C, et al. Trends Biotechnol., 2008,26(11):612-621

    28. [28]

      [28] Nishiyama N, Morimoto Y, Jang W, et al. Adv. Drug Deliv. Rev., 2009,61(4):327-338

    29. [29]

      [29] Couleaud P, Morosini V, Frochot C, et al. Nanoscale, 2010, 2(7):1083-1095

    30. [30]

      [30] Sharman W, van Lier J, Allen C. Adv. Drug Deliv. Rev., 2004,56(1):53-76

    31. [31]

      [31] Solban N, Rizvi I, Hasan T. Lasers Surg. Med., 2006,38(5): 522-531

    32. [32]

      [32] Verma S, Watt G, Mai Z, et al. Photochem. Photobiol., 2007,83(5):996-1005

    33. [33]

      [33] Schwaber J, Cohen E. Nature, 1973,244(5416):444-447

    34. [34]

      [34] Miller G, Lown J. Drug Dev. Res., 1997,42(3/4):182-197

    35. [35]

      [35] Mitsunaga M, Ogawa M, Kosaka N, et al. Nat. Med., 2011, 17(12):1685-U1210

    36. [36]

      [36] Peoples G, Goedegebuure P, Smith R, et al. Proc. Natl. Acad. Sci. U. S. A., 1995,92(2):432-436

    37. [37]

      [37] Ke M, Yeung S, Fong W, et al. Chem. Eur. J., 2012,18(14): 4225-4233

    38. [38]

      [38] Sibrian-Vazquez M, Jensen T, Vicente M. Org. Biomol. Chem., 2010,8(5):1160-1172

    39. [39]

      [39] Sibrian-Vazquez M, Jensen T, Hammer R, et al. J. Med. Chem., 2006,49(4):1364-1372

    40. [40]

      [40] Sibrian-Vazquez M, Jensen T, Vicente M. J. Med. Chem., 2008,51(10):2915-2923

    41. [41]

      [41] Sehgal I, Sibrian-Vazquez M, Vicente M. J. Med. Chem., 2008,51(19):6014-6020

    42. [42]

      [42] Master A, Livingston M, Oleinick N, et al. Mol. Pharm., 2012,9(8):2331-2338

    43. [43]

      [43] Master A, Qi Y, Oleinick N, et al. Nanomedicine, 2012,8(5): 655-664

    44. [44]

      [44] Ali H, Ait-Mohand S, Gosselin S, et al. J. Org. Chem., 2011,76(6):1887-1890

    45. [45]

      [45] Ongarora B, Fontenot K, Hu X, et al. J. Med. Chem., 2012, 55(8):3725-3738

    46. [46]

      [46] Wang C, Delcros J, Cannon L, et al. J. Med. Chem., 2003, 46(24):5129-5138

    47. [47]

      [47] Cosentino C, Bates D. Feedback Control in Systems Biology. Cleveland: CRC Press, 2011.

    48. [48]

      [48] Samor C, Guerrini A, Varchi G, et al. Bioconjugate Chem., 2008,19(11):2270-2279

    49. [49]

      [49] Papadopoulou M, Rosenzweig H, Bloomer W. Bioorg. Med. Chem. Lett., 2004,14(6):1519-1522

    50. [50]

      [50] Eiseman J, Rogers F, Guo Y, et al. Cancer Res., 1998,58 (21):4864-4870

    51. [51]

      [51] Holley J, Mather A, Wheelhouse R, et al. Cancer Res., 1992,52(15):4190-4195

    52. [52]

      [52] Yuan Z, Egorin M, Rosen D, et al. Cancer Res., 1994,54(3): 742-748

    53. [53]

      [53] Cullis P, Green R, Malone M. J. Chem. Soc., Perkin Trans. 2, 1995,0(7):1503-1511

    54. [54]

      [54] Dallavalle S, Giannini G, Alloatti D, et al. J. Med. Chem., 2006,49(17):5177-5186

    55. [55]

      [55] Delcros J, Tomasi S, Carrington S, et al. J. Med. Chem., 2002,45(23):5098-5111

    56. [56]

      [56] Battaglia A, Guerrini A, Baldelli E, et al. Tetrahedron Lett., 2006,47(16):2667-2670

    57. [57]

      [57] Jiang X, Yeung S, Lo P, et al. J. Med. Chem., 2011,54(1): 320-330

    58. [58]

      [58] Jiang X, Lo P, Tsang Y, et al. Chem. Eur. J., 2010,16(16): 4777-4783

    59. [59]

      [59] Siegel G, Albers R, Brady S. Basic Neurochemistry: Molecular, Cellular, and Medical Aspects: Vol.1. Salt Lake City: Academic Press, 2006.

    60. [60]

      [60] Zorlu Y, Dumoulin F, Bouchu D, et al. Tetrahedron Lett., 2010,51(50):6615-6618

    61. [61]

      [61] Liu J, Lo P, Fong W, et al. Org. Biomol. Chem., 2009,7(8): 1583-1591

    62. [62]

      [62] Araki J, Ito K. Soft Matter, 2007,3(12):1456-1473

    63. [63]

      [63] Chen Y, Liu Y. Chem. Soc. Rev., 2010,39(2):495-505

    64. [64]

      [64] Hapiot F, Tilloy S, Monflier E. Chem. Rev., 2006,106(3): 767-781

    65. [65]

      [65] Leng X, Choi C, Luo H, et al. Org. Lett., 2007,9(13):2497-2500

    66. [66]

      [66] Baugh S, Yang Z, Leung D, et al. J. Am. Chem. Soc., 2001, 123(50):12488-12494

    67. [67]

      [67] Ruebner A, Yang Z, Leung D, et al. Proc. Natl. Acad. Sci. U. S. A., 1999,96(26):14692-14693

    68. [68]

      [68] Kralova J, Synytsya A, Pouckova P, et al. Photochem. Photobiol., 2006,82(2):432-438

    69. [69]

      [69] Lau J, Lo P, Fong W, et al. Chem. Eur. J., 2011,17(27): 7569-7577 [70] Lau J, Lo P, Tsang Y, et al. Chem. Commun., 2011,47(34): 9657-9659

    70. [70]

      [71] Johnson L, Walsh M, Chen L. Proc. Natl. Acad. Sci. U. S. A., 1980,77(2):990-994

    71. [71]

      [72] Lee D, Helps S, Macardle P, et al. Neurochem. Res., 2009, 34(10):1857-1866

    72. [72]

      [73] Baracca A, Sgarbi G, Solaini G, et al. BBA-Bioenergetics, 2003,1606(1-3):137-146

    73. [73]

      [74] Ferlini C, Scambia G. Nat. Protocols, 2007,2(12):3111-3114

    74. [74]

      [75] Zhao Z, Chan P, Li H, et al. Inorg. Chem., 2012,51(2):812-821

    75. [75]

      [76] Mao J, Zhang Y, Zhu J, et al. Chem. Commun., 2009,0(8): 908-910

    76. [76]

      [77] Lau J, Lo P, Fong W, et al. J. Med. Chem., 2012,55(11): 5446-5454

  • 加载中
    1. [1]

      Xin Lv Hongxing Zhang Kaibo Duan Wenhui Dai Zhihui Wen Wei Guo Junsheng Hao . Lighting the Way Against Cancer: Photodynamic Therapy. University Chemistry, 2024, 39(5): 70-79. doi: 10.3866/PKU.DXHX202309090

    2. [2]

      Jiahui CHENTingting ZHENGXiuyun ZHANGWei LÜ . Research progress of near-infrared absorption inorganic nanomaterials in photothermal and photodynamic therapy of tumors. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2396-2414. doi: 10.11862/CJIC.20240106

    3. [3]

      Shiyang He Dandan Chu Zhixin Pang Yuhang Du Jiayi Wang Yuhong Chen Yumeng Su Jianhua Qin Xiangrong Pan Zhan Zhou Jingguo Li Lufang Ma Chaoliang Tan . 铂单原子功能化的二维Al-TCPP金属-有机框架纳米片用于增强光动力抗菌治疗. Acta Physico-Chimica Sinica, 2025, 41(5): 100046-. doi: 10.1016/j.actphy.2025.100046

    4. [4]

      Jialiang XUJiabin CUI . Recent biological applications of corroles: From diagnosis to therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2303-2317. doi: 10.11862/CJIC.20240245

    5. [5]

      Siyi ZHONGXiaowen LINJiaxin LIURuyi WANGTao LIANGZhengfeng DENGAo ZHONGCuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093

    6. [6]

      Jian Li Yu Zhang Rongrong Yan Kaiyuan Sun Xiaoqing Liu Zishang Liang Yinan Jiao Hui Bu Xin Chen Jinjin Zhao Jianlin Shi . 高效靶向示踪钙钛矿纳米系统光电增效抗肿瘤. Acta Physico-Chimica Sinica, 2025, 41(5): 100042-. doi: 10.1016/j.actphy.2024.100042

    7. [7]

      Peng GENGGuangcan XIANGWen ZHANGHaichuang LANShuzhang XIAO . Hollow copper sulfide loaded protoporphyrin for photothermal-sonodynamic therapy of cancer cells. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1903-1910. doi: 10.11862/CJIC.20240155

    8. [8]

      Lu XUChengyu ZHANGWenjuan JIHaiying YANGYunlong FU . Zinc metal-organic framework with high-density free carboxyl oxygen functionalized pore walls for targeted electrochemical sensing of paracetamol. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 907-918. doi: 10.11862/CJIC.20230431

    9. [9]

      Lijuan Wang Yuping Ning Jian Li Sha Luo Xiongfei Luo Ruiwen Wang . Enhancing the Advanced Nature of Natural Product Chemistry Laboratory Courses with New Research Findings: A Case Study of the Application of Berberine Hydrochloride in Photodynamic Antimicrobial Films. University Chemistry, 2024, 39(11): 241-250. doi: 10.12461/PKU.DXHX202403017

    10. [10]

      Tingting XUWenjing ZHANGYongbo SONG . Research advances of atomic precision coinage metal nanoclusters in tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2275-2285. doi: 10.11862/CJIC.20240229

    11. [11]

      Wenjing ZHANGXiaoqing WANGZhipeng LIU . Recent developments of inorganic metal complex-based photothermal materials and their applications in photothermal therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2356-2372. doi: 10.11862/CJIC.20240254

    12. [12]

      Di WURuimeng SHIZhaoyang WANGYuehua SHIFan YANGLeyong ZENG . Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1679-1688. doi: 10.11862/CJIC.20240135

    13. [13]

      Shule Liu . Application of SPC/E Water Model in Molecular Dynamics Teaching Experiments. University Chemistry, 2024, 39(4): 338-342. doi: 10.3866/PKU.DXHX202310029

    14. [14]

      Yaling Chen . Basic Theory and Competitive Exam Analysis of Dynamic Isotope Effect. University Chemistry, 2024, 39(8): 403-410. doi: 10.3866/PKU.DXHX202311093

    15. [15]

      Jiayu Gu Siqi Wang Jun Ling . Kinetics of Living Copolymerization: A Brief Discussion. University Chemistry, 2025, 40(4): 100-107. doi: 10.12461/PKU.DXHX202406012

    16. [16]

      Zhuoya WANGLe HEZhiquan LINYingxi WANGLing LI . Multifunctional nanozyme Prussian blue modified copper peroxide: Synthesis and photothermal enhanced catalytic therapy of self-provided hydrogen peroxide. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2445-2454. doi: 10.11862/CJIC.20240194

    17. [17]

      Zizheng LUWanyi SUQin SHIHonghui PANChuanqi ZHAOChengfeng HUANGJinguo PENG . Surface state behavior of W doped BiVO4 photoanode for ciprofloxacin degradation. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 591-600. doi: 10.11862/CJIC.20230225

    18. [18]

      Ruoxi Sun Yiqian Xu Shaoru Rong Chunmiao Han Hui Xu . The Enchanting Collision of Light and Time Magic: Exploring the Footprints of Long Afterglow Lifetime. University Chemistry, 2024, 39(5): 90-97. doi: 10.3866/PKU.DXHX202310001

    19. [19]

      Rui Gao Ying Zhou Yifan Hu Siyuan Chen Shouhong Xu Qianfu Luo Wenqing Zhang . Design, Synthesis and Performance Experiment of Novel Photoswitchable Hybrid Tetraarylethenes. University Chemistry, 2024, 39(5): 125-133. doi: 10.3866/PKU.DXHX202310050

    20. [20]

      Wanmin Cheng Juan Du Peiwen Liu Yiyun Jiang Hong Jiang . Photoinitiated Grignard Reagent Synthesis and Experimental Improvement in Triphenylmethanol Preparation. University Chemistry, 2024, 39(5): 238-242. doi: 10.3866/PKU.DXHX202311066

Metrics
  • PDF Downloads(0)
  • Abstract views(739)
  • HTML views(156)

通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Address:Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888
Powered By info@rhhz.net

/

DownLoad:  Full-Size Img  PowerPoint
Return