Citation: QIN Yi, SHI Pei, GUAN Quan-Yin, SHI Xia, ZHAO Guo-Liang. A Copper(Ⅱ) Complex Constructed by 2-Phenyl-4-selenazole Carboxylic Acid：Synthesis, Crystal Structure and Biological Activity[J]. Chinese Journal of Inorganic Chemistry, ;2013, 29(9): 2013-2020. doi: 10.3969/j.issn.1001-4861.2013.00.266 shu

A Copper(Ⅱ) Complex Constructed by 2-Phenyl-4-selenazole Carboxylic Acid：Synthesis, Crystal Structure and Biological Activity

QIN Yi ¹ ,
SHI Pei ² ,
GUAN Quan-Yin ² ,
SHI Xia ² ,
ZHAO Guo-Liang ^1,2

1.
1 Zhejiang Normal University Xingzhi College, Jinhua, Zhejiang 321004, China;

Received Date: 16 November 2012
Available Online: 1 March 2013
Fund Project: 浙江省自然科学基金(No.Y4080256)资助项目。 (No.Y4080256)

A copper(Ⅱ) complex[Cu₂(NO₃)₂L(phen)₂(H₂O)]NO₃, (HL=2-phenyl-4-selenazole carboxylic acid, phen=1,10-phenanthroline), was synthesized and characterized by elemental analysis and IR spectra. Its crystal structure was determined by single crystal X-ray diffraction method. The complex, C₃₄H₂₄N₈Cu₂O₁₂Se, crystallized in the triclinic system, space group P1. The interaction of the complex with DNA was studied by ethidium bromide (EB) fluorescence spectroscopy. The antibacterial activities of the ligand and the complex against five species of bacteria, Escherichia coli (E. coli), Staphylococcus epidermidis (S. epidermidis), Streptococcus viridans (S. viridans), Staphylococcus aureus (S. aureus) and Acinetobacter baumanii (A. baumanii), were tested respectively. The anticancer activities of the ligand and the complex against human pancreatic cancer line PANC-28 and human hepatocarcinoma line HuH7 were also studied by employing MTT assay. The results revealed that the complex possessed significant biological activity. CCDC: 804066.
- copper(Ⅱ) complex;2-phenyl-4-selenazole carboxylic acid;1,10-phenanthroline;crystal structure;biological activity
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