Citation: HAO Hong-Qing, LI Xin, SUN Jing. Synthesis, Structures and Biological Activities of Chiral Salen-Type Schiff Base Enantiomers[J]. Chinese Journal of Inorganic Chemistry, ;2013, 29(6): 1222-1226. doi: 10.3969/j.issn.1001-4861.2013.00.174 shu

Synthesis, Structures and Biological Activities of Chiral Salen-Type Schiff Base Enantiomers

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1. School of Chemistry and Environment, Jiaying University, Meizhou, Guangdong 514015 China;

Received Date: 24 June 2012
Available Online: 4 January 2013
Fund Project: 国家自然科学基金(No.21101077) (No.21101077)广东省自然科学基金(No. S2011040001705)资助项目。 (No. S2011040001705)

Two chiral Salen-type Schiff base enantiomers, 1R-(2-hydroxy benzimine)-2R-(2-hydroxy naphthylmethylenimine) cyclohexane (1a) and 1S-(2-hydroxy benzimine)-2S-(2-hydroxy naphthylmethylenimine) cyclohexane (1b), synthesized though the solution reactions of phenyl salicylate, trans-1, 2-diaminocyclohexane and 2-hydroxynaphthalene-1-carbaldehyde in 2-propanol, have been characterized by EA, IR, X-ray crystallography, Circular Dichroism (CD) spectrum and biological tests. X-ray crystallography and CD spectrum reveal 1a and 1b are optically chiral enantiomers. Biological tests show that 1a has inhibiting bacteria effects. CCDC: 932330, 1; 932331, 2.
- chiral;enantiomer;circular dichroism;biological activity
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沈阳化工大学材料科学与工程学院沈阳 110142