Citation: ZHANG Tao, QIU Yunguang, LUO Qichao, CHENG Xi, ZHAO Lifen, YAN Xin, PENG Bo, JIANG Hualiang, YANG Huaiyu. Concentration Dependent Effects of Ca²⁺ and Mg²⁺ on the Phosphatidylethanolamine-Phosphatidylglycerol Bilayer[J]. Acta Physico-Chimica Sinica, ;2019, 35(8): 840-849. doi: 10.3866/PKU.WHXB201811016 shu

Concentration Dependent Effects of Ca²⁺ and Mg²⁺ on the Phosphatidylethanolamine-Phosphatidylglycerol Bilayer

ZHANG Tao ¹ ,
QIU Yunguang ^2,3 ,
LUO Qichao ² ,
CHENG Xi ² ,
ZHAO Lifen ² ,
YAN Xin ^2,4 ,
PENG Bo ² ,
JIANG Hualiang ^1,2,3,, ,
YANG Huaiyu ^2,3,,

1.
School of Pharmacy, East China University of Science and Technology, Shanghai 200237, P. R. China
2.
Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, P. R. China
3.
University of Chinese Academy of Sciences, Beijing 100049, P. R. China
4.
School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, P. R. China

Corresponding author: JIANG Hualiang, hljiang@simm.ac.cn YANG Huaiyu, hyyang@simm.ac.cn
Received Date: 12 November 2018
Revised Date: 28 December 2018
Accepted Date: 31 December 2018
Available Online: 3 August 2019
Fund Project: the National Natural Science Foundation of China 21422208The project was supported by the National Natural Science Foundation of China (21422208), and the Special Program for Applied Research on Super Computation of the Applied Research on Super Computation of the NSFC-Guangdong Joint Fund (U1501501)the Special Program for Applied Research on Super Computation of the Applied Research on Super Computation of the NSFC-Guangdong Joint Fund U1501501

Ca²⁺ and Mg²⁺ ions are the main divalent cations in living cells and play vital roles in the structure and function of biological membranes. To date, the differences in the effects of these two ions on the Escherichia coli (E. coli) inner membrane at various concentrations remain unknown. Here, the effects of Ca²⁺ and Mg²⁺ ions on a mixed lipid bilayer composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG) in a 3 : 1 ratio (mol/mol), which mimics the E. coli inner membrane, were quantitatively differentiated at different concentrations by dynamic light scattering (DLS), zeta potential measurements and all-atom molecular dynamics (AA-MD) simulations. The DLS results demonstrated that the POPE/POPG liposomes were homogeneous and monodisperse in solutions with Ca²⁺ or Mg²⁺ ion concentrations of 0 and 1 mmol∙L^-1. As the Ca²⁺ or Mg²⁺ ion concentration was increased to 5-100 mmol∙L^-1, lipid aggregation or the fusion of unilamellar liposomes occurred in the ion solutions. The zeta potential measurements showed that both the Ca²⁺ and Mg²⁺ ions had overcharging effects on the negatively charged POPE/POPG liposomes. The AA-MD simulation results indicated that the Ca²⁺ ions irreversibly adsorbed on the membranes when the simulation time was longer than 100 ns, while the Mg²⁺ ions were observed to dynamically adsorb on and desorb from the membranes at various concentrations. These results are consistent with the DLS and zeta potential experiments. The average numbers of Ca²⁺ and Mg²⁺ ions in the first coordination shell of the oxygen atoms of the phosphate, carbonyl and hydroxyl groups of POPE and POPG (i.e., the first coordination numbers) in the pure membrane and membranes containing 5 and 100 mmol∙L^-1 ions were calculated from the radial distribution functions. The results indicated that the primary binding site of these two ions on POPE and POPG at the concentrations studied was the negatively charged phosphate group. Thus, these results might explain the overcharging effects of both the Ca²⁺ and Mg²⁺ ions on the POPE/POPG liposomes. Moreover, as the Ca²⁺ concentration increased, the area per lipid of the lipid bilayers decreased, and the membrane thickness increased, while the Mg²⁺ ions had negligible effects on these membrane parameters. In addition, these ions had different effects on the orientation of the lipid head groups. These simulation results may be used to provide the possible explanations for the differences between Ca²⁺ and Mg²⁺ ions in DLS and zeta potential measurements at the atomic level. The experimental results and MD simulations provide insight into various biological processes regulated by divalent cations, such as membrane fusion.
- Divalent cation,
- Lipid bilayers,
- Dynamic light scattering,
- Zeta potential,
- Molecular dynamics simulation,
- Interaction
1. [1]
  Edidin, M. Nat. Rev. Mol. Cell Biol. 2003, 4, 414. doi: 10.1038/nrm1102 doi: 10.1038/nrm1102
2. [2]
  Clifton, L. A.; Holt, S. A.; Hughes, A. V.; Daulton, E. L.; Arunmanee, W.; Heinrich, F.; Khalid, S.; Jefferies, D.; Charlton, T. R.; Webster, J. R.; et al. Angew. Chem. Int. Ed. 2015, 54, 11952. doi: 10.1002/anie.201504287 doi: 10.1002/anie.201504287
3. [3]
  Brown, L.; Wolf, J. M.; Prados-Rosales, R.; Casadevall, A. Nat. Rev. Microbiol. 2015, 13, 620. doi: 10.1038/nrmicro3480 doi: 10.1038/nrmicro3480
4. [4]
  Zgurskaya, H. I.; Lopez, C. A.; Gnanakaran, S. ACS Infect. Dis. 2015, 1, 512. doi: 10.1021/acsinfecdis.5b00097 doi: 10.1021/acsinfecdis.5b00097
5. [5]
  Travers, T.; Wang, K. J.; Lopez, C. A.; Gnanakaran, S. Res. Microbiol. 2018, 169, 414. doi: 10.1016/j.resmic.2018.01.002 doi: 10.1016/j.resmic.2018.01.002
6. [6]
  Parkin, J.; Chavent, M.; Khalid, S. Biophys. J. 2015, 109, 461. doi: 10.1016/j.bpj.2015.06.050 doi: 10.1016/j.bpj.2015.06.050
7. [7]
  Jones, H. E.; Holland, I. B.; Campbell, A. K. Cell Calcium 2002, 32, 183. doi: 10.1016/s0143416002001537 doi: 10.1016/s0143416002001537
8. [8]
  Naseem, R.; Wann, K. T.; Holland, I. B.; Campbell, A. K. J. Mol. Biol. 2009, 391, 42. doi: 10.1016/j.jmb.2009.05.064 doi: 10.1016/j.jmb.2009.05.064
9. [9]
  Saier, M. H., Jr. Microbiol. Mol. Biol. Rev. 2000, 64, 354. doi: 10.1128/mmbr.64.2.354-411.2000 doi: 10.1128/mmbr.64.2.354-411.2000
10. [10]
  Shi, X.; Bi, Y.; Yang, W.; Guo, X.; Jiang, Y.; Wan, C.; Li, L.; Bai, Y.; Guo, J.; Wang, Y.; et al. Nature 2013, 493, 111. doi: 10.1038/nature11699 doi: 10.1038/nature11699
11. [11]
  Boettcher, J. M.; Davis-Harrison, R. L.; Clay, M. C.; Nieuwkoop, A. J.; Ohkubo, Y. Z.; Tajkhorshid, E.; Morrissey, J. H.; Rienstra, C. M. Biochemistry 2011, 50, 2264. doi: 10.1021/bi1013694 doi: 10.1021/bi1013694
12. [12]
  Akutsu, H.; Seelig, J. Biochemistry 1981, 20, 7366. doi: 10.1021/bi00529a007 doi: 10.1021/bi00529a007
13. [13]
  Martens, S.; McMahon, H. T. Nat. Rev. Mol. Cell. Biol. 2008, 9, 543. doi: 10.1038/nrm2417 doi: 10.1038/nrm2417
14. [14]
  Ortiz, A.; Killian, J. A.; Verkleij, A. J.; Wilschut, J. Biophys. J. 1999, 77, 2003. doi: 10.1016/s0006-3495(99)77041-4 doi: 10.1016/s0006-3495(99)77041-4
15. [15]
  Friel, D. D.; Chiel, H. J. Trends Neurosci. 2008, 31, 8. doi: 10.1016/j.tins.2007.11.004 doi: 10.1016/j.tins.2007.11.004
16. [16]
  Romani, A. M.; Scarpa, A. Front Biosci. 2000, 5, D720. doi: 10.2741/Romani doi: 10.2741/Romani
17. [17]
  Clifton, L. A.; Skoda, M. W. A.; Le Brun, A. P.; Ciesielski, F.; Kuzmenko, I.; Holt, S. A.; Lakey, J. H. Langmuir 2015, 31, 404. doi: 10.1021/la504407v doi: 10.1021/la504407v
18. [18]
  Montero, M.; Eydallin, G.; Viale, A. M.; Almagro, G.; Munoz, F. J.; Rahimpour, M.; Sesma, M. T.; Baroja-Fernandez, E.; Pozueta-Romero, J. Biochem. J. 2009, 424, 129. doi: 10.1042/bj20090980 doi: 10.1042/bj20090980
19. [19]
  Balsera, M.; Goetze, T. A.; Kovacs-Bogdan, E.; Schurmann, P.; Wagner, R.; Buchanan, B. B.; Soll, J.; Bolter, B. J. Biol. Chem. 2009, 284, 2603. doi: 10.1074/jbc.m807134200 doi: 10.1074/jbc.m807134200
20. [20]
  Kanipes, M. I.; Lin, S.; Cotter, R. J.; Raetz, C. R. J. Biol. Chem. 2001, 276, 1156. doi: 10.1074/jbc.m009019200 doi: 10.1074/jbc.m009019200
21. [21]
  Gangola, P.; Rosen, B. P. J. Biol. Chem. 1987, 262, 12570.
22. [22]
  Dominguez, D. C. Mol. Microbiol. 2004, 54, 291. doi: 10.1111/j.1365-2958.2004.04276.x doi: 10.1111/j.1365-2958.2004.04276.x
23. [23]
  Chaigne-Delalande, B.; Lenardo, M. J. Trends Immunol. 2014, 35, 332. doi: 10.1016/j.it.2014.05.001 doi: 10.1016/j.it.2014.05.001
24. [24]
  Groisman, E. A.; Hollands, K.; Kriner, M. A.; Lee, E. J.; Park, S. Y.; Pontes, M. H. Annu. Rev. Genet. 2013, 47, 625. doi: 10.1146/annurev-genet-051313-051025 doi: 10.1146/annurev-genet-051313-051025
25. [25]
  Suarez-Germa, C.; Domenech, O.; Montero, M. T.; Hernandez-Borrell, J. Biochim. Biophys. Acta-Biomembr. 2014, 1838, 842. doi: 10.1016/j.bbamem.2013.11.015 doi: 10.1016/j.bbamem.2013.11.015
26. [26]
  Tu, Y.; Lv, M.; Xiu, P.; Huynh, T.; Zhang, M.; Castelli, M.; Liu, Z.; Huang, Q.; Fan, C.; Fang, H.; Zhou, R. Nat. Nanotechnol. 2013, 8, 594. doi: 10.1038/nnano.2013.125 doi: 10.1038/nnano.2013.125
27. [27]
  Picas, L.; Carretero-Genevrier, A.; Montero, M. T.; Vazquez-Ibar, J. L.; Seantier, B.; Milhiet, P. E.; Hernandez-Borrell, J. Biochim. Biophys. Acta-Biomembr. 2010, 1798, 1014. doi: 10.1016/j.bbamem.2010.01.008 doi: 10.1016/j.bbamem.2010.01.008
28. [28]
  Mao, Y.; Du, Y.; Cang, X.; Wang, J.; Chen, Z.; Yang, H.; Jiang, H. J. Phys. Chem. B 2013, 117, 850. doi: 10.1021/jp310163z doi: 10.1021/jp310163z
29. [29]
  Tsai, H. H. G.; Lai, W. X.; Lin, H. D.; Lee, J. B.; Juang, W. F.; Tseng, W. H. Biochim. Biophys. Acta-Biomembr. 2012, 1818, 2742. doi: 10.1016/j.bbamem.2012.05.029 doi: 10.1016/j.bbamem.2012.05.029
30. [30]
  Chen, W. Q.; Guan, Y. J.; Zhang, X. P.; Deng, Y. Q. Acta Phys. -Chim. Sin. 2018, 34, 912. doi: 10.3866/PKU.WHXB201801091
31. [31]
  Mao, L.; Yang, L.; Zhang, Q.; Jiang, H.; Yang, H. Biochem. Biophys. Res. Commun. 2015, 468, 125. doi: 10.1016/j.bbrc.2015.10.149 doi: 10.1016/j.bbrc.2015.10.149
32. [32]
  Liu, F. F.; Fan, Y. B.; Liu, Z.; Bai, S. Acta Phys. -Chim. Sin. 2017, 33, 1905. doi: 10.3866/PKU.WHXB201704274
33. [33]
  Liu, F. F.; Dong, X. Y.; Sun, Y. Acta Phys. -Chim. Sin. 2010, 26, 1643. doi: 10.3866/PKU.WHXB20100613
34. [34]
  Zhao, Y. S.; Zheng, Q. C.; Zhang, H. X.; Chu, H. Y.; Sun, J. Z. Acta Phys. -Chim. Sin. 2009, 25, 417. doi: 10.3866/PKU.WHXB20090304
35. [35]
  Melcrova, A.; Pokorna, S.; Pullanchery, S.; Kohagen, M.; Jurkiewicz, P.; Hof, M.; Jungwirth, P.; Cremer, P. S.; Cwiklik, L. Sci. Rep. 2016, 6, 38035. doi: 10.1038/srep38035 doi: 10.1038/srep38035
36. [36]
  Domingues, M. M.; Inacio, R. G.; Raimundo, J. M.; Martins, M.; Castanho, M. A.; Santos, N. C. Biopolymers 2012, 98, 338. doi: 10.1002/bip.22095 doi: 10.1002/bip.22095
37. [37]
  Luo, S. Q.; Wang, M. N.; Zhao, W. W.; Wang, Y. L. Acta Phys. -Chim. Sin. 2019, 35, 766. doi: 10.3866/PKU.WHXB201809038
38. [38]
  Liu, H. C.; Feng, Y. J. Acta Phys. -Chim. Sin. 2019, 35, 408. doi: 10.3866/PKU.WHXB201803051
39. [39]
  Wei, B. Z.; Guo, Z. Y.; Wang, F.; Huang, A. M.; Ma, L. Acta Phys. -Chim. Sin. 2018, 34, 185. doi: 10.3866/PKU.WHXB201707175
40. [40]
  Hendrich, A. B.; Malon, R.; Pola, A.; Shirataki, Y.; Motohashi, N.; Michalak, K. Eur. J. Pharm. Sci. 2002, 16, 201. doi: 10.1016/s0928-0987(02)00106-9 doi: 10.1016/s0928-0987(02)00106-9
41. [41]
  Wu, E. L.; Cheng, X.; Jo, S.; Rui, H.; Song, K. C.; Davila-Contreras, E. M.; Qi, Y.; Lee, J.; Monje-Galvan, V.; Venable, R. M.; et al. J. Comput. Chem. 2014, 35, 1997. doi: 10.1002/jcc.23702 doi: 10.1002/jcc.23702
42. [42]
  Abraham, M. J.; Murtola, T.; Schulz, R.; Páll, S.; Smith, J. C.; Hess, B.; Lindahl, E. SoftwareX 2015, 1-2, 19. doi: 10.1016/j.softx.2015.06.001 doi: 10.1016/j.softx.2015.06.001
43. [43]
  MacKerell, A. D.; Bashford, D.; Bellott, M.; Dunbrack, R. L.; Evanseck, J. D.; Field, M. J.; Fischer, S.; Gao, J.; Guo, H.; Ha, S.; et al. J. Phys. Chem. B 1998, 102, 3586. doi: 10.1021/jp973084f doi: 10.1021/jp973084f
44. [44]
  Bussi, G.; Donadio, D.; Parrinello, M. J. Chem. Phys. 2007, 126, 014101. doi: 10.1063/1.2408420 doi: 10.1063/1.2408420
45. [45]
  Nosé, S. J. Chem. Phys. 1984, 81, 511. doi: 10.1063/1.447334 doi: 10.1063/1.447334
46. [46]
  Nosé, S.; Klein, M. L. Mol. Phys. 1983, 50, 1055. doi: 10.1080/00268978300102851 doi: 10.1080/00268978300102851
47. [47]
  Miyamoto, S.; Kollman, P. A. J. Comput. Chem. 1992, 13, 952. doi: 10.1002/jcc.540130805 doi: 10.1002/jcc.540130805
48. [48]
  Hess, B.; Bekker, H.; Berendsen, H. J. C.; Fraaije, J. G. E. M. J. Comput. Chem. 1997, 18, 1463. doi: 10.1002/(sici)1096-987x(199709)18:12<1463::aid-jcc4>3.0.co;2-h doi: 10.1002/(sici)1096-987x(199709)18:12<1463::aid-jcc4>3.0.co;2-h
49. [49]
  Darden, T.; York, D.; Pedersen, L. J. Chem. Phys. 1993, 98, 10089. doi: 10.1063/1.464397 doi: 10.1063/1.464397
50. [50]
  Guixa-Gonzalez, R.; Rodriguez-Espigares, I.; Ramirez-Anguita, J. M.; Carrio-Gaspar, P.; Martinez-Seara, H.; Giorgino, T.; Selent, J. Bioinformatics 2014, 30, 1478. doi: 10.1093/bioinformatics/btu037 doi: 10.1093/bioinformatics/btu037
51. [51]
  Martin-Molina, A.; Rodriguez-Beas, C.; Faraudo, J. Biophys. J. 2012, 102, 2095. doi: 10.1016/j.bpj.2012.03.009 doi: 10.1016/j.bpj.2012.03.009
52. [52]
  Bockmann, R. A.; Grubmuller, H. Angew. Chem. Int. Ed. 2004, 43, 1021. doi: 10.1002/anie.200352784 doi: 10.1002/anie.200352784
53. [53]
  Rand, R. P.; Fuller, N.; Parsegian, V. A.; Rau, D. C. Biochemistry 1988, 27, 7711. doi: 10.1021/bi00420a021 doi: 10.1021/bi00420a021
54. [54]
  Yang, H.; Xu, Y.; Gao, Z.; Mao, Y.; Du, Y.; Jiang, H. J. Phys. Chem B 2010, 114, 16978. doi: 10.1021/jp1091569 doi: 10.1021/jp1091569
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Concentration Dependent Effects of Ca2+ and Mg2+ on the Phosphatidylethanolamine-Phosphatidylglycerol Bilayer

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Concentration Dependent Effects of Ca²⁺ and Mg²⁺ on the Phosphatidylethanolamine-Phosphatidylglycerol Bilayer