Citation: XIANG Hui-Jing, LIU Jin-Gang, ZHAO Yanli. Recent Research Advancements in NO-Releasing Nanomaterials[J]. Acta Physico-Chimica Sinica, ;2017, 33(5): 903-917. doi: 10.3866/PKU.WHXB201702091 shu

Recent Research Advancements in NO-Releasing Nanomaterials

1.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371;
2.
Key Laboratory for Advanced Materials of MOE, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China

Received Date: 1 December 2016
Revised Date: 3 February 2017

Fund Project: The project was supported by the Singapore Academic Research Fund (RG112/15), NTU-Northwestern Institute for Nanomedicine, and National Natural Science Foundation of China (21571062).

Nitric oxide (NO)—an endogenous diatomic molecule—plays key roles in various physiological and pathological processes, including smooth muscle relaxation in blood vessels, immune response, neurotransmission, respiration, and cell apoptosis. The biological functions of this molecule greatly depend on the location, timing, and dosage at which it is released. It is important to develop NO-delivery platforms capable of holding NO stably during storage and subsequently release optimal amounts of NO spatiotemporally at the desired location and time. In this review, recent advancements in the preparation of new exogenous NO donors including diazeniumdiolates, S-nitrosothiols, nitrobenzene, and metal-nitrosyl complexes are discussed. The integration of these NO donors with various nanoplatforms for controlled NO delivery and their potential applications in the biomedical field are highlighted.
- Controlled release,
- Nanomedicine,
- Nitric oxide,
- Nitric oxide delivery nanoplatform,
- Nitric oxide donor
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沈阳化工大学材料科学与工程学院沈阳 110142