Citation: JI Tian-Yi, LIU Yan-Cheng, ZHAO Jian-Feng, XU Gang, WANG Wen-Feng, WU Ming-Hong. Radical-Induced Degradation of Fluoxetine in Aqueous Solution by Pulse and Steady-State Radiolysis Studies[J]. Acta Physico-Chimica Sinica, ;2017, 33(4): 823-828. doi: 10.3866/PKU.WHXB201701092 shu

Radical-Induced Degradation of Fluoxetine in Aqueous Solution by Pulse and Steady-State Radiolysis Studies

1.
School of Environment and Chemical Engineering, Shanghai University, Shanghai 200444, P. R. China;
2.
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, P. R. China;
3.
University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Received Date: 8 November 2016
Revised Date: 9 January 2017

Fund Project: The project was supported by the National Natural Science Foundation of China (21173252, 41430644, 11675098).

The reactions of the pharmaceutical fluoxetine (FLX) with different radicals were investigated by pulse radiolysis. The reaction of hydroxyl radical (·OH) with FLX formed hydroxylated adduct of the aromatic ring, while oxidation of FLX by sulfate radical anion (SO₄^·-) formed benzene radical cation that further reacted with H₂O to yield the ·OH adduct. The determined rate constants of ·OH, hydrated electrons (e_aq^-), and SO₄^·- with FLX were 7.8×10⁹, 2.3×10⁹, and 1.1×10⁹ mol·L^-1·s^-1, respectively. In the steady-state radiolysis study, the degradation of FLX in different radiolytic conditions by electron beam irradiation was detected by HPLC and UV-Vis spectra techniques. It was found that FLX concentration decreased by more than 90% in both N₂O and air-saturated solutions after 1.5 kGy irradiation. In contrast, only 43% of FLX was decomposed in N₂-saturated solution containing 0.1 mol·L^-1 tert-butanol. The degradation rates of FLX in acidic and neutral solutions were higher than those in alkaline solutions. Our results showed that the degradation of FLX is optimal in air-saturated neutral solution, and ·OH-induced degradation is more efficient than SO₄^·- oxidation of FLX. The obtained kinetic data and optimal conditions give some hints to understand the degradation of FLX.
- Fluoxetine,
- Pulse radiolysis,
- Hydroxyl radical,
- Sulfate radical anion,
- Degradation
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沈阳化工大学材料科学与工程学院沈阳 110142