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Citation: MENG Ming-Cheng, LI Lin-Li, ZHAN Xian-Cheng, TAO Jian-Lin, HAN Xue. Evaluation of the Influence of Humidity and Temperature on the Drug Stability by Plane Single Time Point Experiments[J]. Acta Physico-Chimica Sinica, ;2009, 25(05): 897-904. doi: 10.3866/PKU.WHXB20090501 shu

Evaluation of the Influence of Humidity and Temperature on the Drug Stability by Plane Single Time Point Experiments

1.
Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China

Received Date: 9 December 2008
Available Online: 26 February 2009

The moisture and temperature plane of a drug was determined based on the dispersive principle of uniform design. Then, kinetic parameters were obtained by a single time point experiment. The stability of aspirin, as a solid state model, was investigated. We found that the results obtained from this proposed method were comparable to those from isothermal studies at constant humidity and also comparable to those from the programmed humidifying and heating experiments. Under the same experimental conditions, the estimates of the kinetic parameters (Ea, m, A) obtained from the new method were significantly more accurate and precise than those obtained from the programmed humidifying and heating experiments. No specific computer-controlled environmental chamber needs to be used in our new method. By comparison to isothermal experiments at constant humidity, our proposed method saved time, labor, and materials.
- Plane single time point experiments,
- Classical isothermal experiment at constant humidity,
- Programmed humidifying and heating experiment,
- Simulated test,
- Aspirin
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