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Citation: CHENG Ling-Li, ZHAO Ping, WANG Mei, ZHU Hui, ZHU Rong-Rong, SUN Xiao-Yu, WANG Shi-Long. Photodamage and Photooxidation Mechanisms of Bovine Serum Albumin[J]. Acta Physico-Chimica Sinica, ;2009, 25(01): 25-29. doi: 10.3866/PKU.WHXB20090105 shu

Photodamage and Photooxidation Mechanisms of Bovine Serum Albumin

1.
School of Life Science and Technology, Tongji University, Shanghai 200092, P. R. China

Received Date: 1 January 2008
Available Online: 31 December 2008

Photodamage and photooxidation mechanisms of bovine serumalbumin (BSA) as induced by UVradiation
and one-electron oxidation by SO4-· were investigated by 266 nm laser flash photolysis. BSA can be photoionized and photoexcited by 266 nm photons to give tryptophan (Trp)/NH+·, Trp/N· resulting from the rapid deprotonation of Trp/NH+·, and 3Trp*. Through intermolecular electron transfer between 3Trp* and tyrosine (Tyr), Tyr/O· was produced. In one-electron oxidation of BSA by SO4-· the apparent set up rate constants of Tyr and Trp radicals were calculated but intermolecular electron transfer was not observed. We propose that SO4-· oxidizes BSA by electron transfer to the Tyr and Trp of BSA with a rate constant of 1.51×10¹⁰ L·mol^-1·s^-1. This research provides an introductory theory to enable further study on the redox metabolic process of BSA.
- Bovine serumalbumin; Photo-ionization; Photo-excitation; Electron transfer; One-electron oxidization
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