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Citation: U Guo-Jing, BAO Feng-Juan, XU Hong-Ping, ZHENG Zhi-Xiang. Effects of Drug Release Mediumon Layered Double Hydroxide Carrier[J]. Acta Physico-Chimica Sinica, ;2008, 24(09): 1675-1680. doi: 10.3866/PKU.WHXB20080925 shu

Effects of Drug Release Mediumon Layered Double Hydroxide Carrier

1.
School of Basic Medical Science , Ningxia Medical College, Yinchuan 750004, P. R. China; College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, P. R. China

Received Date: 3 March 2008
Available Online: 26 June 2008

Layered double hydroxide (LDH) had been used as a carrier of acetylsalicylic acid (ASP) to prepare intercalation compound LDH-ASP via ion exchange reaction. The influence of release medium on the carrier was investigated through extrinsic release test and XRD, FT-IR, TEM, TG-DSC, and BET-N2 surface area characterizations. The results showed that the carrier’s laminar features weakened in a pH range from 4.30 to 6.89, but the LDH crystal-class kept unchanged. In a pH range from 2.48 to 4.30, the probable grating reaction between H2PO-4 and hydroxyls of LDH caused laminar carrier transformation into complex phosphates. Along with pH decreased from 6.89 to 2.48, the carrier’s purity decreased, crystallinity weakened, and micro-pore absorbability declined.
- Drug release medium; LDH-ASP intercalation compound; Crystal change; Controlled-release carrier
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Effects of Drug Release Mediumon Layered Double Hydroxide Carrier

南开大学师唯/华北电力大学（保定）刘景维：二维配位聚合物中有序的亲锂冠醚位点用于无枝晶锂沉积

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通讯作者: 陈斌, bchen63@163.com