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Citation: Gao Ying, Lai Lu-Hua. Analysis of Protein-Protein Interface[J]. Acta Physico-Chimica Sinica, ;2004, 20(07): 676-679. doi: 10.3866/PKU.WHXB20040702 shu

Analysis of Protein-Protein Interface

Gao Ying ,
Lai Lu-Hua

1.
State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing　100871

Received Date: 30 March 2004
Available Online: 15 July 2004

Analysis of protein-protein interface is crucial to understand protein interactions and to develop drugs targeting protein complexes. PP_SITE is a method developed by the author's group to deduce hydrogen bond and hydrophobic properties for protein-protein interface. We have used PP_SITE to perform statistical analysis on protein-protein interfaces. A two-chain non-redundant interface dataset from PDB was constructed and used in the study. According to the hydrophobicity and hydrogen bond characteristics, criteria were selected to differentiate protein interfaces into distinct groups. The size of interface, the proportion of hydrophobic and hydrophilic property and the extent of concentration in hydrophobicity were found to be important for interface classification.
- Protein-protein interaction;PP_SITE procedure;Interface classification
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