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Citation: Yang Yong, Duan Li-Li, Li Zhi-Fen, Zeng Hui-Hui, Wang Bao-Huai, Zhang You-Min. Interaction between Actin and Cisplatin or Transplatin[J]. Acta Physico-Chimica Sinica, ;2000, 16(12): 1073-1079. doi: 10.3866/PKU.WHXB20001204 shu

Interaction between Actin and Cisplatin or Transplatin

1.
Institute of Physical Chemistry,Peking University 100871

Received Date: 15 March 2000
Available Online: 15 December 2000

The interaction between actin and cisplatin or transplatin hes been studied by using the 1H-NMR spectra and measuring the critical concentration of actin polymerization.These studies show that both cisplatin and transplatin induce a depolymerization of F-actin,and that the effect of transplatin is more obvious than that of cisplatin at the same concentration.It is found that cisplatin promotes a polymerization of G-actin at low concentration and inhibits it at high concentration.while transplatin inhibits the polymerization at any concentration.The binding sites of cisplatin/transplatin to G-actin are discussen.It is probable that cisplatin binds with Cys-10 and Cys-285,while tracsplatin does not bind with Cys-10.
- Actin,
- Cisplatin,
- Transplatin,
- ¹H-NMR
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